CausalSentinel

Protein Dossier — LDOC1 (Protein LDOC1)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Diagnoses - main ICD10: R11 Nausea and vomiting	-0.351	0.125	0.00498	Wald ratio	1	trans	NA
Alcohol intake frequency	-0.0184	0.00802	0.022	Wald ratio	1	trans	NA
Primary sclerosing cholangitis	-0.171	0.0784	0.0291	Wald ratio	1	trans	NA
Sodium in urine	-0.0114	0.00534	0.0322	Wald ratio	1	trans	NA
Non-cancer illness code self-reported: sleep apnoea	0.172	0.083	0.0384	Wald ratio	1	trans	NA
Diagnoses - main ICD10: C61 Malignant neoplasm of prostate	-0.156	0.0784	0.0463	Wald ratio	1	trans	NA
Cancer code self-reported: prostate cancer	-0.147	0.074	0.0466	Wald ratio	1	trans	NA
Diagnoses - main ICD10: G47 Sleep disorders	0.123	0.0628	0.0499	Wald ratio	1	trans	NA
Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation	-0.0804	0.041	0.0501	Wald ratio	1	trans	NA
Systolic blood pressure automated reading	0.0107	0.00555	0.0534	Wald ratio	1	trans	NA
Non-cancer illness code self-reported: bladder problem (not cancer)	-0.157	0.084	0.061	Wald ratio	1	trans	NA
Squamous cell lung cancer	-0.127	0.0683	0.0623	Wald ratio	1	trans	NA
…and 67 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

No GWAS Catalog associations mapped to this gene.

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

No genetically-associated diseases retrieved from Open Targets.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=0.62, LOEUF=0.963 — LoF-tolerant
GWAS Catalog	1 unique SNPs / 2 rows
ClinVar	216 records; 21 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 121 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘LDOC1’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 216 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — No GWAS Catalog associations mapped to this gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/O95751 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000182195/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/LDOC1 — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/LDOC1 — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LDOC1%5Bgene%5D — ClinVar build Build260809-1055.1

Provenance

• Generated: 2026-08-14T03:29:09 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

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