Protein Dossier — LGALS2 (Galectin-2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Packed cell volume |
-0.23 |
0.0655 |
4.46e-04 |
Wald ratio |
1 |
cis |
NA |
| Haemoglobin concentration |
-0.0727 |
0.0207 |
4.50e-04 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K43 Ventral hernia |
0.307 |
0.101 |
0.00234 |
Wald ratio |
1 |
cis |
NA |
| Age at menopause |
0.182 |
0.0727 |
0.0124 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
-0.0218 |
0.00923 |
0.0179 |
Wald ratio |
1 |
cis |
NA |
| Invasive mucinous ovarian cancer |
0.345 |
0.152 |
0.0229 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate |
0.202 |
0.0912 |
0.0265 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd |
0.259 |
0.121 |
0.0331 |
Wald ratio |
1 |
cis |
NA |
| Lung adenocarcinoma |
-0.208 |
0.0993 |
0.0365 |
Wald ratio |
1 |
cis |
NA |
| Large vessel disease |
-0.262 |
0.126 |
0.0377 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms |
0.132 |
0.0646 |
0.0417 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain |
0.0817 |
0.0402 |
0.0422 |
Wald ratio |
1 |
cis |
NA |
| …and 104 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3033_57_1 |
Galectin-2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
6 association rows across 4 traits (5 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Serum levels of protein LGALS2 |
5e-34 |
rs5756738 |
1 |
GCST90088194 |
no MR -> candidate analysis |
| Galectin-2 levels |
2e-23 |
rs2281097 |
3 |
GCST90161598 |
no MR -> candidate analysis |
| Blood protein levels |
2e-20 |
rs2281097 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Response to anti-depressant treatment in major depressive di |
2e-6 |
rs12157904 |
1 |
GCST001308 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 259 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| placenta praevia |
0.306 |
— |
common-variant locus |
no MR -> candidate analysis |
| crush injury |
0.123 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Galectin-2) |
| gnomAD constraint |
pLI=0.012, LOEUF=1.31 — LoF-tolerant |
| GWAS Catalog |
56 unique SNPs / 110 rows |
| ClinVar |
52 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 259 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘LGALS2’ and resolved to ‘Galectin-2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 52 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 4 of 4 traits by best p-value, aggregated from 6 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P05162 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000100079/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5977/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/LGALS2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LGALS2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LGALS2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LGALS2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:30:25 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none