Protein Dossier — LGALS3BP (Galectin-3-binding protein)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| PGC cross-disorder traits |
-0.225 |
0.0888 |
0.0114 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: psoriasis |
0.288 |
0.116 |
0.0134 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: asthma |
-0.122 |
0.0515 |
0.0179 |
Wald ratio |
1 |
cis |
NA |
| Autism |
-0.435 |
0.199 |
0.0288 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R35 Polyuria |
0.387 |
0.184 |
0.0356 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
-0.0275 |
0.0133 |
0.0387 |
Wald ratio |
1 |
cis |
NA |
| Major depressive disorder |
-0.317 |
0.156 |
0.042 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
0.274 |
0.141 |
0.0516 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Ankle |
0.215 |
0.113 |
0.0577 |
Wald ratio |
1 |
cis |
NA |
| Sleep duration |
0.0233 |
0.0127 |
0.0662 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: prostate cancer |
0.264 |
0.15 |
0.0789 |
Wald ratio |
1 |
cis |
NA |
| Vascular or heart problems diagnosed by doctor: Angina |
0.139 |
0.0798 |
0.0818 |
Wald ratio |
1 |
cis |
NA |
| …and 71 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5000_52_1 |
LG3BP |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
26 association rows across 15 traits (23 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| LGALS3BP protein levels |
1e-77 |
rs111526614 |
3 |
GCST90469760 |
no MR -> candidate analysis |
| CANT1 protein levels |
1e-58 |
rs112832453 |
1 |
GCST90468536 |
no MR -> candidate analysis |
| Galectin-3-binding protein levels |
4e-35 |
rs111526614 |
5 |
GCST90247672 |
no MR -> candidate analysis |
| Circulating DSG4 levels |
3e-30 |
rs55842605 |
1 |
GCST90860253 |
no MR -> candidate analysis |
| DSG4 protein levels |
3e-29 |
rs55842605 |
1 |
GCST90469044 |
no MR -> candidate analysis |
| DSG3/DSG4 protein level ratio |
2e-27 |
rs7220336 |
1 |
GCST90314558 |
no MR -> candidate analysis |
| Height |
7e-17 |
rs4789915 |
3 |
GCST90245848 |
no MR -> candidate analysis |
| Serum levels of protein LGALS3BP |
2e-12 |
rs3826311 |
1 |
GCST90088859 |
no MR -> candidate analysis |
| Total PHF-tau (SNP x SNP interaction) |
2e-12 |
rs4789907 x rs1124952 |
3 |
GCST010340 |
no MR -> candidate analysis |
| Physical function (baseline) |
2e-10 |
rs56352914 |
1 |
GCST90565837 |
no MR -> candidate analysis |
| Metalloproteinase inhibitor 2 levels |
4e-10 |
rs4789927 |
1 |
GCST90424491 |
no MR -> candidate analysis |
| Protein quantitative trait loci (liver) |
2e-8 |
rs58996443 |
1 |
GCST011427 |
no MR -> candidate analysis |
| …and 3 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 339 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| metabolic disease |
0.457 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 1 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Galectin-3-binding protein) |
| gnomAD constraint |
pLI=7.6e-10, LOEUF=1.53 — LoF-tolerant |
| GWAS Catalog |
65 unique SNPs / 130 rows |
| ClinVar |
131 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 339 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘LGALS3BP’ and resolved to ‘Galectin-3-binding protein’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 131 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 15 of 15 traits by best p-value, aggregated from 26 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q08380 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000108679/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6067101/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/LGALS3BP — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LGALS3BP — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LGALS3BP%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LGALS3BP — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:31:00 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none