Protein Dossier — LGALS3 (Galectin-3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.00409 |
0.00108 |
1.56e-04 |
Inverse variance weighted |
3 |
cis |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.00409 |
0.00108 |
1.56e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.00409 |
0.00108 |
1.56e-04 |
Inverse variance weighted |
3 |
trans |
NA |
| Body mass index (BMI) |
0.0152 |
0.00494 |
0.00202 |
Inverse variance weighted |
3 |
cis |
NA |
| Body mass index (BMI) |
0.0152 |
0.00494 |
0.00202 |
Inverse variance weighted |
3 |
trans |
NA |
| Body mass index (BMI) |
0.0152 |
0.00494 |
0.00202 |
Inverse variance weighted |
3 |
trans |
NA |
| Ulcerative colitis |
0.293 |
0.0956 |
0.00218 |
Wald ratio |
1 |
trans |
NA |
| Pulse rate |
0.0248 |
0.00866 |
0.00417 |
Inverse variance weighted |
3 |
cis |
NA |
| Pulse rate |
0.0248 |
0.00866 |
0.00417 |
Inverse variance weighted |
3 |
trans |
NA |
| Pulse rate |
0.0248 |
0.00866 |
0.00417 |
Inverse variance weighted |
3 |
trans |
NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] |
0.00213 |
0.000764 |
0.00533 |
Inverse variance weighted |
3 |
cis |
NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] |
0.00213 |
0.000764 |
0.00533 |
Inverse variance weighted |
3 |
trans |
NA |
| …and 281 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3066_12_1 |
Galectin-3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
28 association rows across 16 traits (26 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating LGALS3 levels |
8e-2158 |
rs2075601 |
3 |
GCST90859927 |
no MR -> candidate analysis |
| LGALS3 protein levels |
5e-278 |
rs78001930 |
8 |
GCST90469761 |
no MR -> candidate analysis |
| Galectin-3 levels |
3e-272 |
rs76424323 |
4 |
GCST90247671 |
no MR -> candidate analysis |
| Protein biomarker |
2e-188 |
rs2274273 |
1 |
GCST001711 |
no MR -> candidate analysis |
| Serum levels of protein LGALS3 |
8e-84 |
rs112796738 |
1 |
GCST90088218 |
no MR -> candidate analysis |
| Blood protein levels |
3e-45 |
rs76426991 |
1 |
GCST006585 |
no MR -> candidate analysis |
| DAAM1 protein levels |
4e-13 |
rs7160523 |
1 |
GCST90468941 |
no MR -> candidate analysis |
| Red cell distribution width |
8e-11 |
rs8012156 |
1 |
GCST90002404 |
no MR -> candidate analysis |
| Triglycerides to total lipids ratio in chylomicrons and extr |
2e-9 |
rs750614951 |
1 |
GCST90093051 |
no MR -> candidate analysis |
| Galectin 3 plasma levels |
1e-8 |
rs6573005 |
1 |
GCST90085736 |
no MR -> candidate analysis |
| Cholesteryl esters to total lipids ratio in chylomicrons and |
2e-8 |
rs750614951 |
1 |
GCST90093043 |
no MR -> candidate analysis |
| T-cell surface glycoprotein CD3 epsilon chain protein levels |
2e-8 |
rs112756125 |
1 |
GCST90443215 |
no MR -> candidate analysis |
| …and 4 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2160 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Hypercholesterolemia |
0.365 |
— |
common-variant locus |
MR: beta=0.00759, p=0.308 (cis) |
| osteoarthritis |
0.263 |
— |
common-variant locus |
MR: beta=0.0935, p=0.124 (cis) |
| arthropathy |
0.256 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
3 known modulators (Galectin-3) |
| gnomAD constraint |
pLI=3.1e-06, LOEUF=1.29 — LoF-tolerant |
| GWAS Catalog |
42 unique SNPs / 82 rows |
| ClinVar |
73 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
1 clinical annotations across 1 drugs |
phenome — Top 30 of 2160 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘LGALS3’ and resolved to ‘Galectin-3’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 73 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 16 of 16 traits by best p-value, aggregated from 28 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P17931 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000131981/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4531/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/LGALS3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LGALS3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LGALS3%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=LGALS3 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/LGALS3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:30:41 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none