Protein Dossier — LGALS4 (Galectin-4)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Pulse rate |
0.133 |
0.0234 |
1.50e-08 |
Wald ratio |
1 |
cis |
NA |
| Lumbar spine bone mineral density |
0.191 |
0.0486 |
8.26e-05 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
0.0532 |
0.0136 |
9.20e-05 |
Wald ratio |
1 |
cis |
NA |
| Femoral neck bone mineral density |
0.161 |
0.0418 |
1.18e-04 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
0.0652 |
0.0204 |
0.00143 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal |
0.27 |
0.0865 |
0.00181 |
Wald ratio |
1 |
cis |
NA |
| HDL cholesterol |
-0.0823 |
0.0265 |
0.00191 |
Wald ratio |
1 |
cis |
NA |
| Lung cancer |
-0.319 |
0.105 |
0.0024 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: vitiligo |
0.996 |
0.339 |
0.00328 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.056 |
0.0197 |
0.00436 |
Wald ratio |
1 |
cis |
NA |
| Serum creatinine (eGFRcrea) |
-0.0144 |
0.00508 |
0.00471 |
Wald ratio |
1 |
cis |
NA |
| Mean platelet volume |
-0.0155 |
0.00608 |
0.0109 |
Wald ratio |
1 |
cis |
NA |
| …and 111 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2982_82_2 |
Galectin-4 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
7 association rows across 5 traits (7 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating LGALS7_LGALS7B levels |
6e-55 |
rs58866020 |
2 |
GCST90860535 |
no MR -> candidate analysis |
| LGALS7 or LGALS7B protein levels |
9e-52 |
rs58866020 |
2 |
GCST90469763 |
no MR -> candidate analysis |
| Blood protein levels |
2e-33 |
rs4802890 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Enoyl-CoA delta isomerase 2, mitochondrial levels |
4e-22 |
rs4802890 |
1 |
GCST90247387 |
no MR -> candidate analysis |
| Phosphatidylcholines (35:2)B levels |
3e-8 |
rs116923791 |
1 |
GCST90102044 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 370 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Transient global amnesia |
0.155 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary artery disorder |
0.052 |
— |
common-variant locus |
no MR -> candidate analysis |
| Bell’s palsy |
0.082 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Galectin-4) |
| gnomAD constraint |
pLI=2e-12, LOEUF=1.23 — LoF-tolerant |
| GWAS Catalog |
60 unique SNPs / 120 rows |
| ClinVar |
67 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 370 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘LGALS4’ and resolved to ‘Galectin-4’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 67 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 5 of 5 traits by best p-value, aggregated from 7 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P56470 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000171747/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1671608/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/LGALS4 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LGALS4 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LGALS4%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LGALS4 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:31:16 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none