CausalSentinel

Protein Dossier — LILRA5 (Leukocyte immunoglobulin-like receptor subfamily A member 5)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
HDL cholesterol	-0.0687	0.0103	2.72e-11	Wald ratio	1	cis	3.71e-17
Crohn’s disease	0.0906	0.0251	3.03e-04	Wald ratio	1	cis	NA
Cigarettes smoked per day	0.531	0.174	0.00232	Wald ratio	1	cis	NA
Diagnoses - main ICD10: H25 Senile cataract	-0.201	0.0662	0.00239	Wald ratio	1	cis	NA
Inflammatory bowel disease	0.0608	0.0207	0.00335	Wald ratio	1	cis	NA
Diagnoses - main ICD10: I30 Acute pericarditis	0.473	0.174	0.00658	Wald ratio	1	cis	NA
Diagnoses - main ICD10: I48 Atrial fibrillation and flutter	0.108	0.0402	0.007	Wald ratio	1	cis	NA
Forearm bone mineral density	0.0744	0.0307	0.0152	Wald ratio	1	cis	NA
Diastolic blood pressure automated reading	-0.0107	0.00484	0.0268	Wald ratio	1	cis	NA
Hirschsprung’s disease	0.564	0.261	0.0309	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: hiatus hernia	0.0608	0.0292	0.0373	Wald ratio	1	cis	NA
Cancer code self-reported: basal cell carcinoma	0.0934	0.045	0.038	Wald ratio	1	cis	NA
…and 97 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

348 association rows across 195 traits (339 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.

Trait	best p	lead SNP	n assoc	study	MR status
Leukocyte immunoglobulin-like receptor subfamily A member 3	8e-2417	rs367070	3	GCST90248297	no MR -> candidate analysis
Circulating LILRB1 levels	1e-2035	rs367070	1	GCST90860494	no MR -> candidate analysis
Circulating LILRA5 levels	2e-803	rs404032	1	GCST90860363	no MR -> candidate analysis
Blood protein levels	1e-568	rs398217	24	GCST006585	no MR -> candidate analysis
High density lipoprotein cholesterol levels	4e-251	rs367070	18	GCST90239649	no MR -> candidate analysis
Leukocyte immunoglobulin-like receptor subfamily A member 5	2e-227	rs651279	4	GCST90248299	no MR -> candidate analysis
Circulating LILRB5 levels	1e-219	rs397600	1	GCST90860424	no MR -> candidate analysis
LILRB2 protein levels	1e-168	rs192800970	10	GCST90469777	no MR -> candidate analysis
LILRA3 protein levels	2e-163	rs103294	11	GCST90453333	no MR -> candidate analysis
Serum levels of protein LILRB2	2e-154	rs431420	1	GCST90089109	no MR -> candidate analysis
Leukocyte immunoglobulin-like receptor subfamily B member 2	5e-126	rs116877265	4	GCST90162285	no MR -> candidate analysis
High-density lipoprotein levels	2e-124	rs367070	2	GCST90662894	no MR -> candidate analysis
…and 183 more traits (see JSON)

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

Top diseases by Open Targets association (of 89 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.

Disease	genetic assoc.	burden (ExWAS)	causal status	MR status
Alzheimer disease	0.555	—	common-variant locus	no MR -> candidate analysis
metabolic syndrome	0.241	—	common-variant locus	no MR -> candidate analysis
late-onset Alzheimers disease	0.117	—	common-variant locus	no MR -> candidate analysis
physical activity	0.033	—	common-variant locus	no MR -> candidate analysis
prostate carcinoma	0.032	—	common-variant locus	no MR -> candidate analysis
alcohol drinking	0.031	—	common-variant locus	no MR -> candidate analysis

Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=8.8e-10, LOEUF=1.15 — LoF-tolerant
GWAS Catalog	231 unique SNPs / 560 rows
ClinVar	73 records; 1 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 89 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘LILRA5’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 73 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — Top 20 of 195 traits by best p-value, aggregated from 348 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/A6NI73 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000187116/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/LILRA5 — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/LILRA5 — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LILRA5%5Bgene%5D — ClinVar build Build260809-1055.1
• gwas_traits: https://www.ebi.ac.uk/gwas/genes/LILRA5 — GWAS Catalog search API (live; release not exposed)

Provenance

• Generated: 2026-08-14T03:33:24 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

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