MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: H25 Senile cataract | -0.113 | 0.0404 | 0.00496 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K44 Diaphragmatic hernia | 0.0586 | 0.0238 | 0.014 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C50 Malignant neoplasm of breast | 0.0565 | 0.0233 | 0.0154 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | -0.0648 | 0.029 | 0.0255 | Wald ratio | 1 | cis | NA |
| Femoral neck bone mineral density | 0.0223 | 0.0102 | 0.0294 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) | -0.095 | 0.0456 | 0.0373 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | 0.052 | 0.0259 | 0.0451 | Wald ratio | 1 | cis | NA |
| Potassium in urine | -0.00642 | 0.0032 | 0.0452 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vitiligo | 0.288 | 0.147 | 0.0503 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I84 Haemorrhoids | -0.04 | 0.0211 | 0.0585 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.0517 | 0.0283 | 0.0684 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.00916 | 0.00533 | 0.0858 | Wald ratio | 1 | cis | NA |
| …and 59 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
8 association rows across 5 traits (8 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Leukocyte immunoglobulin-like receptor subfamily A member 6 | 8e-255 | rs71257443 | 2 | GCST90248300 | no MR -> candidate analysis |
| LILRA6 protein levels | 1e-123 | rs7246690 | 2 | GCST90469775 | no MR -> candidate analysis |
| Leukocyte immunoglobulin-like receptor subfamily A member 6 | 6e-122 | rs61734497 | 2 | GCST90241792 | no MR -> candidate analysis |
| LILRB1 protein levels | 4e-102 | rs61002408 | 1 | GCST90469776 | no MR -> candidate analysis |
| OSCAR protein levels | 3e-23 | rs61002408 | 1 | GCST90470131 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 52 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| response to statin | 0.113 | — | common-variant locus | no MR -> candidate analysis |
| Crohn disease | 0.054 | — | common-variant locus | no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.451 — LoF-INTOLERANT |
| GWAS Catalog | 282 unique SNPs / 726 rows |
| ClinVar | 56 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 52 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LILRA6’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 56 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 5 of 5 traits by best p-value, aggregated from 8 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q6PI73 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000244482/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LILRA6 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LILRA6 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LILRA6%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LILRA6 — GWAS Catalog search API (live; release not exposed)