Protein Dossier — LILRB1 (Leukocyte immunoglobulin-like receptor subfamily B member 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Juvenile idiopathic arthritis |
0.126 |
0.0748 |
0.0934 |
Wald ratio |
1 |
cis |
NA |
| Lung cancer |
0.019 |
0.0218 |
0.383 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: prostate cancer |
0.0264 |
0.035 |
0.45 |
Wald ratio |
1 |
cis |
NA |
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5090_49_2 |
ILT-2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
51 association rows across 26 traits (45 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Leukocyte immunoglobulin-like receptor subfamily B member 1 |
4e-1083 |
rs10426886 |
8 |
GCST90248301 |
no MR -> candidate analysis |
| Circulating LILRB1 levels |
1e-460 |
rs112988186 |
2 |
GCST90860494 |
no MR -> candidate analysis |
| Leukocyte immunoglobulin-like receptor subfamily B member 1 |
1e-336 |
rs2114511 |
5 |
GCST90241793 |
no MR -> candidate analysis |
| LILRB1 protein levels |
9e-189 |
rs8101262 |
3 |
GCST90469776 |
no MR -> candidate analysis |
| Leukocyte immunoglobulin-like receptor subfamily B member 1 |
3e-103 |
rs10427127 |
1 |
GCST90237833 |
no MR -> candidate analysis |
| LAIR2 protein levels |
1e-99 |
rs16985478 |
2 |
GCST90469729 |
no MR -> candidate analysis |
| LILRA2 protein levels |
9e-80 |
rs184207698 |
3 |
GCST90469771 |
no MR -> candidate analysis |
| Serum levels of protein LILRB1 |
3e-65 |
rs145320563 |
1 |
GCST90088913 |
no MR -> candidate analysis |
| KIR2DS4 protein levels |
9e-38 |
rs575822772 |
4 |
GCST90469686 |
no MR -> candidate analysis |
| Circulating LILRB4 levels |
1e-35 |
rs10426886 |
2 |
GCST90860196 |
no MR -> candidate analysis |
| LILRB4 protein levels |
3e-34 |
rs190610084 |
3 |
GCST90469778 |
no MR -> candidate analysis |
| KIR3DL1 protein levels |
5e-25 |
rs575822772 |
1 |
GCST90469687 |
no MR -> candidate analysis |
| …and 14 more traits (see JSON) |
|
|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 292 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Epstein-Barr virus infection |
0.341 |
— |
common-variant locus |
no MR -> candidate analysis |
| response to stimulus |
0.172 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=2.6e-16, LOEUF=0.983 — LoF-tolerant |
| GWAS Catalog |
150 unique SNPs / 392 rows |
| ClinVar |
221 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 292 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LILRB1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 221 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 26 traits by best p-value, aggregated from 51 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q8NHL6 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000104972/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LILRB1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LILRB1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LILRB1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LILRB1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:34:13 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none