Protein Dossier — LILRB2 (Leukocyte immunoglobulin-like receptor subfamily B member 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| HDL cholesterol |
-0.0451 |
0.00696 |
9.48e-11 |
Wald ratio |
1 |
cis |
4.83e-19 |
| Pulse rate |
-0.0156 |
0.00462 |
7.45e-04 |
Wald ratio |
1 |
cis |
NA |
| Bulimia nervosa |
-0.0452 |
0.0165 |
0.0062 |
Wald ratio |
1 |
cis |
NA |
| Hirschsprung’s disease |
0.341 |
0.126 |
0.00696 |
Wald ratio |
1 |
cis |
NA |
| Total cholesterol |
-0.0201 |
0.00774 |
0.00945 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
-0.0482 |
0.0191 |
0.0115 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.063 |
0.0256 |
0.0137 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis |
-0.0586 |
0.0239 |
0.0144 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin concentration |
-0.0142 |
0.00592 |
0.0165 |
Wald ratio |
1 |
cis |
NA |
| Cigarettes smoked per day |
0.512 |
0.22 |
0.0202 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I30 Acute pericarditis |
0.264 |
0.116 |
0.0231 |
Wald ratio |
1 |
cis |
NA |
| Depressive symptoms |
0.00957 |
0.00435 |
0.0278 |
Wald ratio |
1 |
cis |
NA |
| …and 92 more outcomes (see JSON) |
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|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5091_28_3 |
ILT-4 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
67 association rows across 39 traits (57 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating LILRB2 levels |
1e-4990 |
rs383925 |
3 |
GCST90860493 |
no MR -> candidate analysis |
| Leukocyte immunoglobulin-like receptor subfamily B member 2 |
2e-1606 |
rs448092 |
4 |
GCST90248302 |
no MR -> candidate analysis |
| Leukocyte immunoglobulin-like receptor subfamily B member 2 |
5e-530 |
rs386056 |
5 |
GCST90241794 |
no MR -> candidate analysis |
| LILRB5 protein levels |
3e-301 |
rs192506020 |
6 |
GCST90469779 |
no MR -> candidate analysis |
| LILRA6 protein levels |
2e-269 |
rs421685 |
4 |
GCST90469775 |
no MR -> candidate analysis |
| Serum levels of protein LILRB2 |
2e-203 |
rs373032 |
2 |
GCST90089109 |
no MR -> candidate analysis |
| Leukocyte immunoglobulin-like receptor subfamily B member 2 |
6e-172 |
rs383925 |
1 |
GCST90426236 |
no MR -> candidate analysis |
| Circulating LILRB5 levels |
7e-122 |
rs149260334 |
1 |
GCST90860424 |
no MR -> candidate analysis |
| Blood protein levels |
8e-117 |
rs373032 |
1 |
GCST006585 |
no MR -> candidate analysis |
| LILRA3 protein levels |
1e-96 |
rs113133716 |
3 |
GCST90469772 |
no MR -> candidate analysis |
| Circulating LILRA5 levels |
2e-96 |
rs13347079 |
1 |
GCST90860363 |
no MR -> candidate analysis |
| LILRB1 protein levels |
6e-37 |
rs113133716 |
2 |
GCST90469776 |
no MR -> candidate analysis |
| …and 27 more traits (see JSON) |
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|
|
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 222 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Alzheimer disease |
0.607 |
— |
common-variant locus |
no MR -> candidate analysis |
| chronic obstructive pulmonary disease |
0.523 |
— |
common-variant locus |
no MR -> candidate analysis |
| metabolic syndrome |
0.449 |
— |
common-variant locus |
no MR -> candidate analysis |
| Erythema nodosum |
0.165 |
— |
common-variant locus |
no MR -> candidate analysis |
| Chronic Obstructive Asthma |
0.154 |
— |
common-variant locus |
no MR -> candidate analysis |
| prostate carcinoma |
0.092 |
— |
common-variant locus |
no MR -> candidate analysis |
| physical activity |
0.095 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.089 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 8 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=2.7e-10, LOEUF=0.824 — LoF-tolerant |
| GWAS Catalog |
247 unique SNPs / 652 rows |
| ClinVar |
184 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 222 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LILRB2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 184 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 39 traits by best p-value, aggregated from 67 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q8N423 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000131042/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LILRB2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LILRB2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LILRB2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LILRB2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:34:37 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none