CausalSentinel

Protein Dossier — LILRB5 (Leukocyte immunoglobulin-like receptor subfamily B member 5)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Hirschsprung’s disease	-0.569	0.183	0.00188	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: diverticular disease or diverticulitis	0.0521	0.019	0.00603	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt	0.0569	0.0221	0.0102	Wald ratio	1	cis	NA
Schizophrenia	0.0259	0.0103	0.0121	Wald ratio	1	cis	NA
Bulimia nervosa	0.0181	0.00862	0.0357	Wald ratio	1	cis	NA
Diagnoses - main ICD10: K35 Acute appendicitis	0.0562	0.0287	0.0501	Wald ratio	1	cis	NA
Diagnoses - main ICD10: R14 Flatulence and related conditions	0.149	0.0762	0.0512	Wald ratio	1	cis	NA
Multiple sclerosis	0.0271	0.0143	0.0572	Wald ratio	1	cis	NA
Fractured bone site(s): Arm	0.0383	0.0205	0.0617	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: bone disorder	-0.0908	0.0495	0.0664	Wald ratio	1	cis	NA
Eye problems or disorders: Cataract	-0.0213	0.0118	0.0704	Wald ratio	1	cis	NA
Non-cancer illness code self-reported: chronic obstructive airways disease or copd	-0.0691	0.0388	0.0754	Wald ratio	1	cis	NA
…and 70 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

298 association rows across 223 traits (291 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.

Trait	best p	lead SNP	n assoc	study	MR status
Circulating LILRB5 levels	4e-6679	rs10405357	5	GCST90860424	no MR -> candidate analysis
Leukocyte immunoglobulin-like receptor subfamily B member 5	1e-3690	rs12975366	2	GCST90248305	no MR -> candidate analysis
Leukocyte immunoglobulin-like receptor subfamily B member 5	3e-1276	rs12975366	2	GCST90241798	no MR -> candidate analysis
Blood protein levels	3e-433	rs10405357	8	GCST006585	no MR -> candidate analysis
Cerebrospinal fluid protein LILRB5 levels	1e-254	rs12975366	1	GCST90944814	no MR -> candidate analysis
Serum levels of protein LILRB5	1e-247	rs6509859	2	GCST90089622	no MR -> candidate analysis
GALNT7 protein levels	5e-240	rs12975366	2	GCST90469299	no MR -> candidate analysis
LILRB2 protein levels	3e-238	rs2361796	6	GCST90469777	no MR -> candidate analysis
LILRA6 protein levels	1e-188	rs74387320	7	GCST90469775	no MR -> candidate analysis
Creatine kinase levels	1e-183	rs12975366	4	GCST90838680	no MR -> candidate analysis
Serum levels of protein LILRB2	2e-171	rs595872	1	GCST90089109	no MR -> candidate analysis
LILRB5 protein levels	3e-166	rs180761831	4	GCST90469779	no MR -> candidate analysis
…and 211 more traits (see JSON)

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

Top diseases by Open Targets association (of 62 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.

Disease	genetic assoc.	burden (ExWAS)	causal status	MR status
Alzheimer disease	0.328	—	common-variant locus	no MR -> candidate analysis
Chronic Obstructive Asthma	0.222	—	common-variant locus	no MR -> candidate analysis
placenta praevia	0.22	—	common-variant locus	no MR -> candidate analysis
metabolic syndrome	0.212	—	common-variant locus	no MR -> candidate analysis
response to statin	0.106	—	common-variant locus	no MR -> candidate analysis
non-autoimmune hemolytic anemia	0.071	—	common-variant locus	no MR -> candidate analysis

Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=5.8e-19, LOEUF=1.1 — LoF-tolerant
GWAS Catalog	280 unique SNPs / 718 rows
ClinVar	162 records; 0 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 62 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘LILRB5’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 162 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — Top 20 of 223 traits by best p-value, aggregated from 298 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/O75023 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000105609/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/LILRB5 — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/LILRB5 — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LILRB5%5Bgene%5D — ClinVar build Build260809-1055.1
• gwas_traits: https://www.ebi.ac.uk/gwas/genes/LILRB5 — GWAS Catalog search API (live; release not exposed)

Provenance

• Generated: 2026-08-14T03:35:24 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

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