MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Bipolar disorder | -0.499 | 0.0989 | 4.57e-07 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) | 1.07 | 0.254 | 2.60e-05 | Wald ratio | 1 | cis | NA |
| Schizophrenia | -0.173 | 0.043 | 5.66e-05 | Wald ratio | 1 | cis | NA |
| Systemic lupus erythematosus | -0.75 | 0.189 | 6.94e-05 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.0364 | 0.00999 | 2.70e-04 | Wald ratio | 1 | cis | NA |
| PGC cross-disorder traits | -0.164 | 0.0491 | 8.55e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.0805 | 0.0244 | 9.53e-04 | Wald ratio | 1 | cis | NA |
| HbA1C | 0.0426 | 0.0137 | 0.00186 | Wald ratio | 1 | cis | NA |
| Juvenile idiopathic arthritis | 0.656 | 0.216 | 0.00241 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.183 | 0.0621 | 0.00325 | Wald ratio | 1 | cis | NA |
| Red blood cell count | 0.0274 | 0.00989 | 0.00562 | Wald ratio | 1 | cis | NA |
| Paget’s disease | -0.645 | 0.242 | 0.00755 | Wald ratio | 1 | cis | NA |
| …and 107 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
31 association rows across 18 traits (27 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Calcium levels | 3e-51 | rs72941253 | 1 | GCST90018951 | no MR -> candidate analysis |
| Height | 3e-45 | rs6746896 | 5 | GCST90245848 | MR: beta=-0.0186, p=0.126 (cis) |
| magnesium (Mg, mean, inv-norm transformed) | 1e-25 | rs968470 | 1 | GCST90479679 | no MR -> candidate analysis |
| VIP36-like protein levels (LMAN2L.8013.9.3) | 4e-24 | rs2271893 | 1 | GCST90243343 | no MR -> candidate analysis |
| VIP36-like protein levels | 2e-23 | rs2271893 | 2 | GCST90427209 | no MR -> candidate analysis |
| Serum levels of protein LMAN2L | 9e-22 | rs72809827 | 1 | GCST90089985 | no MR -> candidate analysis |
| magnesium (Mg, minimum, inv-norm transformed) | 2e-20 | rs968470 | 1 | GCST90479680 | no MR -> candidate analysis |
| magnesium (Mg, maximum, inv-norm transformed) | 4e-15 | rs968470 | 1 | GCST90479678 | no MR -> candidate analysis |
| Aspartate aminotransferase levels | 4e-13 | rs968470 | 1 | GCST90662897 | no MR -> candidate analysis |
| Blood protein levels | 2e-12 | rs2271893 | 1 | GCST006585 | no MR -> candidate analysis |
| Forced expiratory volume (baseline) | 4e-11 | rs189255944 | 1 | GCST90565844 | no MR -> candidate analysis |
| Bipolar disorder | 5e-11 | rs4619651 | 6 | GCST012465 | MR: beta=-0.499, p=4.57e-07 (cis) |
| …and 6 more traits (see JSON) |
Top diseases by Open Targets association (of 74 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| autosomal recessive non-syndromic intellectual disability | 0.695 | — | established (curated) | no MR -> candidate analysis |
| bipolar disorder | 0.841 | — | common-variant locus | MR: beta=-0.499, p=4.57e-07 (cis) |
| intellectual disability, autosomal dominant 52 | 0.608 | — | established (curated) | no MR -> candidate analysis |
| intellectual developmental disorder, autosomal dominant 69 | 0.547 | — | established (curated) | no MR -> candidate analysis |
| schizophrenia | 0.508 | — | common-variant locus | MR: beta=-0.173, p=5.66e-05 (cis) |
| major depressive disorder | 0.508 | — | common-variant locus | MR: beta=-0.0656, p=0.445 (cis) |
| attention deficit-hyperactivity disorder | 0.508 | — | common-variant locus | no MR -> candidate analysis |
| autism spectrum disorder | 0.508 | — | common-variant locus | no MR -> candidate analysis |
| anorexia nervosa | 0.508 | — | common-variant locus | MR: beta=-0.186, p=0.106 (cis) |
| obsessive-compulsive disorder | 0.508 | — | common-variant locus | no MR -> candidate analysis |
| Tourette syndrome | 0.508 | — | common-variant locus | no MR -> candidate analysis |
| bipolar I disorder | 0.504 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.455 | — | common-variant locus | no MR -> candidate analysis |
| neurodevelopmental disorder | 0.195 | — | established (curated) | no MR -> candidate analysis |
| hyperphosphatasia-intellectual disability syndrome | 0.195 | — | established (curated) | no MR -> candidate analysis |
Of the 15 rows above, 11 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2.1e-07, LOEUF=0.918 — LoF-tolerant |
| GWAS Catalog | 33 unique SNPs / 66 rows |
| ClinVar | 151 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 74 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LMAN2L’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 151 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 18 of 18 traits by best p-value, aggregated from 31 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9H0V9 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000114988/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LMAN2L — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LMAN2L — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LMAN2L%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LMAN2L — GWAS Catalog search API (live; release not exposed)