MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: high cholesterol | 0.114 | 0.00844 | 1.09e-41 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | 0.252 | 0.0193 | 5.39e-39 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | 0.205 | 0.016 | 9.99e-38 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.224 | 0.0211 | 2.37e-26 | Wald ratio | 1 | cis | NA |
| Total cholesterol | 0.0986 | 0.0112 | 9.33e-19 | Wald ratio | 1 | cis | NA |
| LDL cholesterol | 0.0935 | 0.0114 | 2.22e-16 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest | 0.0665 | 0.0146 | 5.29e-06 | Wald ratio | 1 | cis | NA |
| Serum creatinine (eGFRcrea) | -0.00797 | 0.00183 | 1.37e-05 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine | 0.0681 | 0.023 | 0.0031 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0169 | 0.00587 | 0.00404 | Wald ratio | 1 | cis | NA |
| Large vessel disease | 0.181 | 0.0722 | 0.0122 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R35 Polyuria | 0.121 | 0.0498 | 0.0154 | Wald ratio | 1 | cis | NA |
| …and 99 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
2538 association rows across 929 traits (2489 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Lipoprotein (a) levels | 6e-22136 | rs10455872 | 61 | GCST011087 | no MR -> candidate analysis |
| Triglyceride levels in chylomicrons and extremely large VLDL | 8e-1032 | rs10455872 | 6 | GCST90501340 | no MR -> candidate analysis |
| Total lipid levels in chylomicrons and extremely large VLDL | 8e-929 | rs10455872 | 6 | GCST90501336 | no MR -> candidate analysis |
| Cholesterol to Total Lipids in Chylomicrons and Extremely La | 1e-891 | rs10455872 | 3 | GCST90501331 | no MR -> candidate analysis |
| Triglycerides to Total Lipids in Chylomicrons and Extremely | 1e-814 | rs10455872 | 3 | GCST90501341 | no MR -> candidate analysis |
| Concentration of chylomicrons and extremely large VLDL parti | 1e-813 | rs10455872 | 7 | GCST90501337 | no MR -> candidate analysis |
| Phospholipid levels in chylomicrons and extremely large VLDL | 1e-808 | rs10455872 | 5 | GCST90501338 | no MR -> candidate analysis |
| Free cholesterol levels in chylomicrons and extremely large | 1e-789 | rs10455872 | 5 | GCST90501334 | no MR -> candidate analysis |
| Free Cholesterol to Total Lipids in Chylomicrons and Extreme | 5e-750 | rs10455872 | 3 | GCST90501335 | no MR -> candidate analysis |
| Cholesteryl Esters to Total Lipids in Chylomicrons and Extre | 6e-722 | rs10455872 | 3 | GCST90501333 | no MR -> candidate analysis |
| Cholesterol levels in chylomicrons and extremely large VLDL | 2e-710 | rs10455872 | 4 | GCST90501330 | no MR -> candidate analysis |
| Average diameter for VLDL particles | 2e-649 | rs10455872 | 5 | GCST90501292 | no MR -> candidate analysis |
| …and 917 more traits (see JSON) |
Top diseases by Open Targets association (of 576 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| cardiovascular disorder | 0.909 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.894 | — | common-variant locus | no MR -> candidate analysis |
| myocardial infarction | 0.879 | — | common-variant locus | MR: beta=0.224, p=2.37e-26 (cis) |
| heart disorder | 0.899 | — | common-variant locus | no MR -> candidate analysis |
| Hypercholesterolemia | 0.888 | — | common-variant locus | MR: beta=0.114, p=1.09e-41 (cis) |
| atherosclerosis | 0.849 | — | common-variant locus | no MR -> candidate analysis |
| hypertensive disorder | 0.865 | — | common-variant locus | no MR -> candidate analysis |
| angina pectoris | 0.868 | — | common-variant locus | no MR -> candidate analysis |
| myocardial ischemia | 0.848 | — | common-variant locus | no MR -> candidate analysis |
| coronary atherosclerosis | 0.85 | — | common-variant locus | no MR -> candidate analysis |
| peripheral vascular disease | 0.851 | — | common-variant locus | no MR -> candidate analysis |
| metabolic disease | 0.847 | — | common-variant locus | no MR -> candidate analysis |
| hyperlipidemia | 0.84 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.801 | — | common-variant locus | no MR -> candidate analysis |
| congestive heart failure | 0.839 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 2 known modulators (LPA mRNA) |
| gnomAD constraint | pLI=2.1e-68, LOEUF=1.13 — LoF-tolerant |
| GWAS Catalog | 271 unique SNPs / 690 rows |
| ClinVar | 365 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 3 clinical annotations across 2 drugs |
phenome — Top 30 of 576 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘LPA’ and resolved to ‘LPA mRNA’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 365 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 929 traits by best p-value, aggregated from 2538 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P08519 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000198670/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4662965/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/LPA — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LPA — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LPA%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=LPA — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/LPA — GWAS Catalog search API (live; release not exposed)