Protein Dossier — LRIG3 (Leucine-rich repeats and immunoglobulin-like domains protein 3)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: hypopituitarism |
0.903 |
0.316 |
0.00431 |
Wald ratio |
1 |
cis |
NA |
| Hip osteoarthritis |
-0.358 |
0.136 |
0.00834 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin concentration |
0.0582 |
0.0221 |
0.00836 |
Wald ratio |
1 |
cis |
NA |
| Cardioembolic stroke |
0.395 |
0.166 |
0.0173 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bone disorder |
0.435 |
0.184 |
0.0182 |
Wald ratio |
1 |
cis |
NA |
| Ischemic stroke |
0.191 |
0.0837 |
0.0228 |
Wald ratio |
1 |
cis |
NA |
| Years of schooling |
-0.0324 |
0.0151 |
0.0321 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Wrist |
0.158 |
0.0786 |
0.0439 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter |
0.2 |
0.1 |
0.0465 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis |
0.0915 |
0.0482 |
0.0576 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] |
-0.252 |
0.14 |
0.073 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level |
0.401 |
0.228 |
0.0789 |
Wald ratio |
1 |
cis |
NA |
| …and 82 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3322_52_2 |
LRIG3 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
47 association rows across 37 traits (36 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Leucine-rich repeats and immunoglobulin-like domains protein |
9e-50 |
rs144365133 |
4 |
GCST90137846 |
no MR -> candidate analysis |
| Serum levels of protein LRIG3 |
5e-29 |
rs11172775 |
2 |
GCST90088314 |
no MR -> candidate analysis |
| LRIG3 protein levels |
3e-28 |
rs17619704 |
1 |
GCST90469795 |
no MR -> candidate analysis |
| Blood protein levels |
2e-26 |
rs76158750 |
1 |
GCST006585 |
no MR -> candidate analysis |
| Leucine-rich repeats and immunoglobulin-like domains protein |
9e-20 |
rs144365133 |
1 |
GCST90237314 |
no MR -> candidate analysis |
| GLIPR1 protein levels |
9e-18 |
rs138919132 |
1 |
GCST90469357 |
no MR -> candidate analysis |
| Osteoarthritis (with total hip replacement) |
5e-15 |
rs17120227 |
2 |
GCST90566802 |
no MR -> candidate analysis |
| Leucine-rich repeats and immunoglobulin-like domains protein |
5e-14 |
rs11172791 |
1 |
GCST90241785 |
no MR -> candidate analysis |
| INHBC protein levels |
3e-13 |
rs117621242 |
1 |
GCST90469615 |
no MR -> candidate analysis |
| Osteoarthritis (hip) |
4e-13 |
rs79056043 |
2 |
GCST90566798 |
MR: beta=-0.358, p=0.00834 (cis) |
| Physical function (baseline) |
7e-13 |
rs990887 |
1 |
GCST90565837 |
no MR -> candidate analysis |
| Smoking initiation |
3e-12 |
rs10877196 |
2 |
GCST90243985 |
no MR -> candidate analysis |
| …and 25 more traits (see JSON) |
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|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 558 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| osteoarthritis, hip |
0.761 |
— |
common-variant locus |
MR: beta=-0.358, p=0.00834 (cis) |
| total hip arthroplasty |
0.686 |
— |
common-variant locus |
no MR -> candidate analysis |
| smoking initiation |
0.652 |
— |
common-variant locus |
no MR -> candidate analysis |
| esophageal disorder |
0.555 |
— |
common-variant locus |
no MR -> candidate analysis |
| osteoarthritis |
0.548 |
— |
common-variant locus |
MR: beta=-0.358, p=0.00834 (cis) |
| cholesteatoma of middle ear |
0.503 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 6 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=1.1e-16, LOEUF=0.804 — LoF-tolerant |
| GWAS Catalog |
33 unique SNPs / 65 rows |
| ClinVar |
174 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 558 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LRIG3’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 174 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 37 traits by best p-value, aggregated from 47 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q6UXM1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000139263/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LRIG3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LRIG3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LRIG3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LRIG3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:36:56 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none