MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Forearm bone mineral density | 0.0556 | 0.02 | 0.00544 | Wald ratio | 1 | trans | NA |
| Total cholesterol | 0.0169 | 0.0067 | 0.0116 | Wald ratio | 1 | trans | NA |
| Red blood cell count | -0.00742 | 0.00309 | 0.0164 | Wald ratio | 1 | trans | NA |
| Neuroticism | -0.00928 | 0.00412 | 0.0244 | Wald ratio | 1 | trans | NA |
| Alzheimer’s disease | 0.047 | 0.0217 | 0.0299 | Wald ratio | 1 | trans | NA |
| Serum cystatin C (eGFRcys) | -0.00505 | 0.00237 | 0.0331 | Wald ratio | 1 | trans | NA |
| Femoral neck bone mineral density | 0.0194 | 0.00954 | 0.0425 | Wald ratio | 1 | trans | NA |
| HDL cholesterol | 0.012 | 0.00619 | 0.0532 | Wald ratio | 1 | trans | NA |
| Internalizing problems | -0.0755 | 0.0417 | 0.07 | Wald ratio | 1 | trans | NA |
| High grade serous ovarian cancer | 0.036 | 0.0205 | 0.0785 | Wald ratio | 1 | trans | NA |
| Neo-openness to experience | 0.149 | 0.0895 | 0.095 | Wald ratio | 1 | trans | NA |
| Rheumatoid arthritis | 0.0314 | 0.0189 | 0.0964 | Wald ratio | 1 | trans | NA |
| …and 35 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
1 association rows across 1 traits (0 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Emphysema annual change measurement in smokers (adjusted lun | 7e-6 | rs145997721 | 1 | GCST008477 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 68 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| sign or symptom | 0.06 | — | common-variant locus | no MR -> candidate analysis |
| sialadenitis | 0.049 | — | common-variant locus | no MR -> candidate analysis |
| aneurysm | 0.048 | — | common-variant locus | no MR -> candidate analysis |
| nephrotic syndrome | 0.035 | — | common-variant locus | no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=8.9e-12, LOEUF=1.33 — LoF-tolerant |
| GWAS Catalog | 13 unique SNPs / 26 rows |
| ClinVar | 155 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 68 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LRRC19’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 155 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 1 of 1 traits by best p-value, aggregated from 1 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9H756 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000184434/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LRRC19 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LRRC19 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LRRC19%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LRRC19 — GWAS Catalog search API (live; release not exposed)