MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Depressive symptoms | 0.0803 | 0.0292 | 0.00596 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb | 0.28 | 0.102 | 0.00624 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | 0.272 | 0.117 | 0.0207 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | -0.0724 | 0.0323 | 0.025 | Wald ratio | 1 | cis | NA |
| Hearing difficulty or problems: Yes | 0.0625 | 0.0286 | 0.0287 | Wald ratio | 1 | cis | NA |
| Mean platelet volume | -0.0175 | 0.00803 | 0.0291 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.158 | 0.0784 | 0.0443 | Wald ratio | 1 | cis | NA |
| HOMA-IR | -0.0606 | 0.0307 | 0.0481 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoporosis | -0.457 | 0.239 | 0.0558 | Wald ratio | 1 | cis | NA |
| Microalbuminuria | -0.285 | 0.153 | 0.0633 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis | 0.286 | 0.158 | 0.0705 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: enlarged prostate | 0.22 | 0.123 | 0.0729 | Wald ratio | 1 | cis | NA |
| …and 90 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
168 association rows across 114 traits (101 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 1e-300 | rs148727583 | 4 | GCST90321120 | no MR -> candidate analysis |
| Refractive error | 4e-214 | rs11602008 | 7 | GCST90841196 | no MR -> candidate analysis |
| Myopia | 9e-66 | rs11606250 | 2 | GCST003997 | no MR -> candidate analysis |
| Spherical equivalent | 9e-51 | rs11602008 | 4 | GCST010378 | no MR -> candidate analysis |
| Primary angle-closure glaucoma (MTAG) | 1e-50 | rs11606250 | 1 | GCST90832185 | no MR -> candidate analysis |
| Myopia (age of diagnosis) | 5e-49 | rs11602008 | 1 | GCST006290 | no MR -> candidate analysis |
| Spherical equivalent or myopia (age of diagnosis) | 2e-44 | rs11602008 | 1 | GCST006291 | no MR -> candidate analysis |
| Refractive error (autorefraction measured) | 1e-42 | rs11602008 | 1 | GCST90244789 | no MR -> candidate analysis |
| Age-related eyesight deterioration (confirmatory factor anal | 5e-33 | rs11602008 | 1 | GCST90309361 | no MR -> candidate analysis |
| Age started wearing glasses (UKB data field 2217) | 6e-31 | rs11602008 | 1 | GCST90468156 | no MR -> candidate analysis |
| Smoking initiation | 2e-30 | rs10837649 | 9 | GCST90243985 | no MR -> candidate analysis |
| Drinks per week | 4e-28 | rs2956781 | 4 | GCST90243989 | no MR -> candidate analysis |
| …and 102 more traits (see JSON) |
Top diseases by Open Targets association (of 115 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| alcohol drinking | 0.671 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.652 | — | common-variant locus | no MR -> candidate analysis |
| urolithiasis | 0.649 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.621 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.615 | — | common-variant locus | no MR -> candidate analysis |
| myopia | 0.598 | — | common-variant locus | no MR -> candidate analysis |
| Parkinson disease | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.537 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.529 | — | common-variant locus | no MR -> candidate analysis |
| Hypermetropia | 0.526 | — | common-variant locus | no MR -> candidate analysis |
| refractive error | 0.524 | — | common-variant locus | no MR -> candidate analysis |
| gastroduodenitis | 0.52 | — | common-variant locus | no MR -> candidate analysis |
| smoking behavior | 0.512 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.485 | — | common-variant locus | MR: beta=-0.595, p=0.0771 (cis) |
| autoimmune disorder of musculoskeletal system | 0.485 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.313 — LoF-INTOLERANT |
| GWAS Catalog | 122 unique SNPs / 245 rows |
| ClinVar | 93 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 115 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LRRC4C’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 93 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 114 traits by best p-value, aggregated from 168 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9HCJ2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000148948/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LRRC4C — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LRRC4C — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LRRC4C%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LRRC4C — GWAS Catalog search API (live; release not exposed)