MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Forced expiratory volume in 1-second (FEV1) | 0.0367 | 0.00891 | 3.85e-05 | Wald ratio | 1 | cis | NA |
| Weight | 0.0247 | 0.00909 | 0.00654 | Wald ratio | 1 | cis | NA |
| Bipolar disorder | 0.267 | 0.0988 | 0.00678 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | 0.0225 | 0.00845 | 0.00786 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bone disorder | 0.4 | 0.151 | 0.00813 | Wald ratio | 1 | cis | NA |
| Thyroid cancer | -0.86 | 0.36 | 0.017 | Wald ratio | 1 | cis | NA |
| Rheumatoid arthritis | -0.159 | 0.0695 | 0.0218 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: vaginal prolapse or uterine prolapse | 0.25 | 0.11 | 0.0231 | Wald ratio | 1 | cis | NA |
| Type 2 diabetes | -0.198 | 0.0885 | 0.0251 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] | -0.203 | 0.0918 | 0.0267 | Wald ratio | 1 | cis | NA |
| Glioma | 0.378 | 0.18 | 0.0357 | Wald ratio | 1 | cis | NA |
| Internalizing problems | -0.204 | 0.098 | 0.0376 | Wald ratio | 1 | cis | NA |
| …and 86 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
15 association rows across 8 traits (12 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating LRRN1 levels | 2e-55 | rs543062071 | 2 | GCST90860552 | no MR -> candidate analysis |
| LRRN1 protein levels | 3e-55 | rs7648844 | 7 | GCST90469806 | no MR -> candidate analysis |
| Gut microbial network clusters (SkyBlue (at 3 months) x Any | 8e-9 | rs17037086 | 1 | GCST90569272 | no MR -> candidate analysis |
| Adventurousness | 1e-8 | rs6807234 | 1 | GCST007324 | no MR -> candidate analysis |
| Gut microbial network clusters (Salmon (at 1 year) x Any Bre | 1e-8 | rs62247368 | 1 | GCST90569461 | no MR -> candidate analysis |
| beta-nerve growth factor levels | 7e-6 | rs66515854 | 1 | GCST004421 | no MR -> candidate analysis |
| 5-bromotryptophan levels in elite athletes | 7e-6 | rs17037518 | 1 | GCST90133535 | no MR -> candidate analysis |
| Waist circumference adjusted for body mass index | 8e-6 | rs767244068 | 1 | GCST008161 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 135 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| alcohol drinking | 0.682 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.623 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.57 | — | common-variant locus | no MR -> candidate analysis |
| tooth disorder | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| risk-taking behaviour | 0.516 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.512 | — | common-variant locus | no MR -> candidate analysis |
| methicillin-resistant staphylococcus aureus infectious disease | 0.51 | — | common-variant locus | no MR -> candidate analysis |
| response to antihypertensive drug | 0.419 | — | common-variant locus | no MR -> candidate analysis |
| intervertebral disk degenerative disorder | 0.408 | — | common-variant locus | no MR -> candidate analysis |
| substance abuse | 0.408 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.408 | — | common-variant locus | no MR -> candidate analysis |
| mental disorder | 0.404 | — | common-variant locus | no MR -> candidate analysis |
| hemorrhage | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| complication | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.394 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.99, LOEUF=0.478 — LoF-INTOLERANT |
| GWAS Catalog | 74 unique SNPs / 148 rows |
| ClinVar | 206 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 135 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘LRRN1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 206 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 8 of 8 traits by best p-value, aggregated from 15 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O75427 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000175928/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/LRRN1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/LRRN1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=LRRN1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/LRRN1 — GWAS Catalog search API (live; release not exposed)