MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Clear cell ovarian cancer | -0.671 | 0.201 | 8.25e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: depression | 0.135 | 0.0438 | 0.00207 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: H25 Senile cataract | 0.303 | 0.103 | 0.00332 | Wald ratio | 1 | cis | NA |
| Sleep duration | 0.0262 | 0.00947 | 0.00572 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | 0.281 | 0.103 | 0.00617 | Wald ratio | 1 | cis | NA |
| Schizophrenia | 0.141 | 0.0533 | 0.00801 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoarthritis | 0.0961 | 0.0369 | 0.00919 | Wald ratio | 1 | cis | NA |
| Happiness | -0.0345 | 0.0151 | 0.0218 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema | -0.143 | 0.0625 | 0.0219 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | 0.132 | 0.0599 | 0.0279 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: uterine fibroids | -0.27 | 0.131 | 0.0391 | Wald ratio | 1 | cis | NA |
| Neuroticism | -0.0381 | 0.019 | 0.0455 | Wald ratio | 1 | cis | NA |
| …and 67 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
53 association rows across 36 traits (48 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB levels | 4e-110 | rs35505705 | 5 | GCST90248373 | no MR -> candidate analysis |
| CD101 protein levels | 8e-60 | rs181883268 | 1 | GCST90468596 | no MR -> candidate analysis |
| Smoking initiation | 1e-29 | rs3820500 | 2 | GCST90243985 | no MR -> candidate analysis |
| Serum levels of protein MAN1A2 | 4e-24 | rs111711406 | 2 | GCST90090492 | no MR -> candidate analysis |
| Circulating AGER levels | 9e-23 | rs7517996 | 2 | GCST90859774 | no MR -> candidate analysis |
| White blood cell count | 2e-22 | rs34368125 | 2 | GCST90026503 | no MR -> candidate analysis |
| Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB levels (MA | 1e-20 | rs35505705 | 1 | GCST90241874 | no MR -> candidate analysis |
| Circulating GPC1 levels | 8e-19 | rs2359248 | 2 | GCST90860018 | no MR -> candidate analysis |
| TFF1/TFF2 protein level ratio | 1e-17 | rs58694069 | 1 | GCST90315914 | no MR -> candidate analysis |
| Educational attainment | 1e-16 | rs73002120 | 2 | GCST90105038 | no MR -> candidate analysis |
| Circulating BCAN levels | 1e-16 | rs6667019 | 2 | GCST90859689 | no MR -> candidate analysis |
| GPC1 protein levels | 3e-16 | rs4460623 | 1 | GCST90469386 | no MR -> candidate analysis |
| …and 24 more traits (see JSON) |
Top diseases by Open Targets association (of 292 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| insomnia | 0.535 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.534 | — | common-variant locus | no MR -> candidate analysis |
| injury | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| chronic primary adrenal insufficiency | 0.466 | — | common-variant locus | no MR -> candidate analysis |
| familial glucocorticoid deficiency | 0.466 | — | common-variant locus | no MR -> candidate analysis |
| skin disorder | 0.456 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.449 | — | common-variant locus | no MR -> candidate analysis |
| diabetic ketoacidosis | 0.443 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.432 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.356 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.331 | — | common-variant locus | no MR -> candidate analysis |
| obstructive sleep apnea syndrome | 0.299 | — | common-variant locus | no MR -> candidate analysis |
Of the 12 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.99, LOEUF=0.476 — LoF-INTOLERANT |
| GWAS Catalog | 109 unique SNPs / 260 rows |
| ClinVar | 73 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 292 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘MAN1A2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 73 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 36 traits by best p-value, aggregated from 53 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O60476 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000198162/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/MAN1A2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/MAN1A2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=MAN1A2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/MAN1A2 — GWAS Catalog search API (live; release not exposed)