Protein Dossier — MAPK13 (Mitogen-activated protein kinase 13)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Red blood cell count |
0.0382 |
0.00946 |
5.31e-05 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
0.183 |
0.061 |
0.00265 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus |
0.206 |
0.0749 |
0.00591 |
Wald ratio |
1 |
cis |
NA |
| Birth length |
-0.112 |
0.0422 |
0.00795 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
-0.116 |
0.0473 |
0.0143 |
Wald ratio |
1 |
cis |
NA |
| Height |
-0.0307 |
0.013 |
0.0181 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.191 |
0.0816 |
0.0191 |
Wald ratio |
1 |
cis |
NA |
| Subjective well being |
-0.0276 |
0.0118 |
0.0196 |
Wald ratio |
1 |
cis |
NA |
| Mean cell haemoglobin |
-0.0981 |
0.0437 |
0.0249 |
Wald ratio |
1 |
cis |
NA |
| Knee and hip osteoarthritis |
0.192 |
0.0866 |
0.0265 |
Wald ratio |
1 |
cis |
NA |
| Mean cell volume |
-0.247 |
0.112 |
0.0265 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
0.165 |
0.0757 |
0.0297 |
Wald ratio |
1 |
cis |
NA |
| …and 97 more outcomes (see JSON) |
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|
|
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5006_71_1 |
MK13 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
6 association rows across 6 traits (5 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| SEMA3G protein levels |
6e-57 |
rs147247331 |
1 |
GCST90470571 |
no MR -> candidate analysis |
| Height |
1e-49 |
rs9689522 |
1 |
GCST90245848 |
MR: beta=-0.0307, p=0.0181 (cis) |
| Mitogen-activated protein kinase 13 levels |
2e-37 |
rs12210904 |
1 |
GCST90248406 |
no MR -> candidate analysis |
| Mitogen-activated protein kinase 13 levels (MAPK13.5006.71.1 |
2e-21 |
rs12210904 |
1 |
GCST90241949 |
no MR -> candidate analysis |
| MAPK13 protein levels |
5e-17 |
rs12210904 |
1 |
GCST90469856 |
no MR -> candidate analysis |
| Alcohol use frequency in adolescence |
5e-6 |
rs115149227 |
1 |
GCST90454589 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 225 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| attention deficit-hyperactivity disorder |
0.438 |
— |
common-variant locus |
no MR -> candidate analysis |
| substance abuse |
0.438 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.049 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 3 rows above, 3 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Mitogen-activated protein kinase 13) |
| gnomAD constraint |
pLI=3.3e-10, LOEUF=0.952 — LoF-tolerant |
| GWAS Catalog |
50 unique SNPs / 100 rows |
| ClinVar |
79 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 225 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘MAPK13’ and resolved to ‘Mitogen-activated protein kinase 13’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 79 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 6 of 6 traits by best p-value, aggregated from 6 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O15264 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000156711/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2939/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/MAPK13 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/MAPK13 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=MAPK13%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/MAPK13 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:43:56 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none