Protein Dossier — MAPKAPK2 (MAP kinase-activated protein kinase 2)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Ulcerative colitis |
0.23 |
0.0421 |
4.84e-08 |
Wald ratio |
1 |
cis |
NA |
| Inflammatory bowel disease |
0.169 |
0.0336 |
4.63e-07 |
Wald ratio |
1 |
cis |
NA |
| Childhood intelligence |
-0.143 |
0.0423 |
7.53e-04 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.358 |
0.112 |
0.00138 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
0.207 |
0.0784 |
0.0083 |
Wald ratio |
1 |
cis |
NA |
| Crohn’s disease |
0.0945 |
0.0407 |
0.0202 |
Wald ratio |
1 |
cis |
NA |
| Chronic kidney disease |
0.113 |
0.0491 |
0.0208 |
Wald ratio |
1 |
cis |
NA |
| Multiple sclerosis |
-0.126 |
0.0548 |
0.0213 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions |
0.495 |
0.216 |
0.0217 |
Wald ratio |
1 |
cis |
NA |
| High grade serous ovarian cancer |
-0.113 |
0.0515 |
0.0283 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: L03 Cellulitis |
0.165 |
0.0765 |
0.031 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.143 |
0.0663 |
0.031 |
Wald ratio |
1 |
cis |
NA |
| …and 107 more outcomes (see JSON) |
|
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|
|
|
|
|
2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3820_68_2 |
MAPK2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
14 association rows across 10 traits (10 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| MAP kinase-activated protein kinase 2 levels |
8e-129 |
rs10863805 |
2 |
GCST90248478 |
no MR -> candidate analysis |
| MAPKAPK2 protein levels |
6e-86 |
rs11119390 |
1 |
GCST90469858 |
no MR -> candidate analysis |
| Height |
6e-40 |
rs4311892 |
2 |
GCST90245848 |
no MR -> candidate analysis |
| Mouth ulcers |
1e-19 |
rs3813961 |
1 |
GCST007839 |
no MR -> candidate analysis |
| IL19 protein levels |
8e-19 |
rs782170878 |
1 |
GCST90469568 |
no MR -> candidate analysis |
| Mitogen-activated protein kinase 14 levels |
3e-18 |
rs11119385 |
1 |
GCST90248407 |
no MR -> candidate analysis |
| Mean corpuscular hemoglobin |
2e-12 |
rs45514798 |
2 |
GCST90002390 |
no MR -> candidate analysis |
| Crohn’s disease |
3e-7 |
rs61815628 |
2 |
GCST90301327 |
MR: beta=0.0945, p=0.0202 (cis) |
| Crohn’s disease x sex interaction (2df) |
4e-7 |
rs61815628 |
1 |
GCST90301328 |
no MR -> candidate analysis |
| Plasma PCSK9 levels |
9e-7 |
rs17015194 |
1 |
GCST90085917 |
no MR -> candidate analysis |
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 400 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| migraine disorder |
0.553 |
— |
common-variant locus |
no MR -> candidate analysis |
| glomerulonephritis |
0.459 |
— |
common-variant locus |
no MR -> candidate analysis |
| sialolithiasis |
0.363 |
— |
common-variant locus |
no MR -> candidate analysis |
| neurodevelopmental disorder |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
| type 2 diabetes mellitus |
0.085 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.085 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 6 rows above, 6 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (MAP kinase-activated protein kinase 2) |
| gnomAD constraint |
pLI=1, LOEUF=0.322 — LoF-INTOLERANT |
| GWAS Catalog |
57 unique SNPs / 114 rows |
| ClinVar |
77 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 400 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘MAPKAPK2’ and resolved to ‘MAP kinase-activated protein kinase 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 77 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 10 of 10 traits by best p-value, aggregated from 14 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P49137 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000162889/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2208/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/MAPKAPK2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/MAPKAPK2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=MAPKAPK2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/MAPKAPK2 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:44:12 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none