MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: R11 Nausea and vomiting | 0.519 | 0.162 | 0.00132 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.403 | 0.148 | 0.00647 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertension | 0.0696 | 0.0263 | 0.0082 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.0347 | 0.0136 | 0.0107 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: small intestine or small bowel cancer | 0.902 | 0.37 | 0.0149 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.0341 | 0.0143 | 0.0174 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K80 Cholelithiasis | 0.221 | 0.0933 | 0.018 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R04 Haemorrhage from respiratory passages | 0.373 | 0.164 | 0.0227 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema | 0.137 | 0.0644 | 0.0335 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd | 0.378 | 0.204 | 0.0643 | Wald ratio | 1 | cis | NA |
| Squamous cell lung cancer | 0.351 | 0.194 | 0.0704 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: osteoarthritis | 0.0898 | 0.0508 | 0.077 | Wald ratio | 1 | cis | NA |
| …and 66 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
25 association rows across 23 traits (18 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| USP8/WASF1 protein level ratio | 6e-1016 | rs7748253 | 1 | GCST90315944 | no MR -> candidate analysis |
| CEP43/WASF1 protein level ratio | 4e-750 | rs7748253 | 1 | GCST90314023 | no MR -> candidate analysis |
| MPHOSPH8/WASF1 protein level ratio | 2e-687 | rs7748253 | 1 | GCST90315481 | no MR -> candidate analysis |
| GYS1/WASF1 protein level ratio | 7e-629 | rs7748253 | 1 | GCST90315006 | no MR -> candidate analysis |
| ITGB1BP2/WASF1 protein level ratio | 5e-599 | rs7748253 | 1 | GCST90315224 | no MR -> candidate analysis |
| BAG6/WASF1 protein level ratio | 1e-446 | rs7748253 | 1 | GCST90313452 | no MR -> candidate analysis |
| IRAG2/WASF1 protein level ratio | 1e-432 | rs7748253 | 1 | GCST90315192 | no MR -> candidate analysis |
| STAT5B/WASF1 protein level ratio | 3e-402 | rs7748253 | 1 | GCST90315889 | no MR -> candidate analysis |
| Circulating WASF1 levels | 6e-163 | rs6939019 | 1 | GCST90860560 | no MR -> candidate analysis |
| Methyltransferase-like protein 24 levels | 4e-63 | rs2334321 | 2 | GCST90427820 | no MR -> candidate analysis |
| Platelet distribution width | 2e-26 | rs6939019 | 1 | GCST90002401 | no MR -> candidate analysis |
| WASF1 protein levels | 4e-16 | rs6568643 | 1 | GCST90471067 | no MR -> candidate analysis |
| …and 11 more traits (see JSON) |
Top diseases by Open Targets association (of 33 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| COVID-19 | 0.47 | — | common-variant locus | no MR -> candidate analysis |
| lung abscess | 0.421 | — | common-variant locus | no MR -> candidate analysis |
| bronchopneumonia | 0.421 | — | common-variant locus | no MR -> candidate analysis |
| digestive system disorder | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| response to xenobiotic stimulus | 0.314 | — | common-variant locus | no MR -> candidate analysis |
| esophageal ulcer | 0.314 | — | common-variant locus | no MR -> candidate analysis |
| Crohn disease | 0.235 | — | common-variant locus | no MR -> candidate analysis |
| Oral leukoplakia | 0.06 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.059 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.05 | — | common-variant locus | no MR -> candidate analysis |
| Nasal polyposis | 0.044 | — | common-variant locus | no MR -> candidate analysis |
| fever of unknown origin | 0.034 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.031 | — | common-variant locus | no MR -> candidate analysis |
Of the 13 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1.6e-09, LOEUF=1.21 — LoF-tolerant |
| GWAS Catalog | 58 unique SNPs / 116 rows |
| ClinVar | 100 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 33 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘METTL24’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 100 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 23 traits by best p-value, aggregated from 25 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q5JXM2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000053328/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/METTL24 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/METTL24 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=METTL24%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/METTL24 — GWAS Catalog search API (live; release not exposed)