Protein Dossier — MIF (Anti-Muellerian hormone)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: gout |
0.143 |
0.0553 |
0.00957 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: bladder problem (not cancer) |
0.184 |
0.0835 |
0.0276 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter |
-0.249 |
0.118 |
0.0345 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
0.174 |
0.0839 |
0.0381 |
Wald ratio |
1 |
trans |
NA |
| Hirschsprung’s disease |
-0.947 |
0.461 |
0.04 |
Wald ratio |
1 |
trans |
NA |
| Body fat |
-0.0344 |
0.0169 |
0.042 |
Wald ratio |
1 |
trans |
NA |
| Underlying (primary) cause of death: ICD10: E85.4 Organ-limited amyloidosis |
1.35 |
0.664 |
0.0421 |
Wald ratio |
1 |
trans |
NA |
| Neo-neuroticism |
0.576 |
0.294 |
0.0504 |
Wald ratio |
1 |
trans |
NA |
| Neo-agreeableness |
-0.368 |
0.19 |
0.0526 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: hypertension |
0.023 |
0.0127 |
0.0687 |
Wald ratio |
1 |
trans |
NA |
| Lung cancer |
0.106 |
0.0586 |
0.0701 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions |
0.4 |
0.225 |
0.0752 |
Wald ratio |
1 |
trans |
NA |
| …and 105 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-4923_79_1 |
MIS |
Suhre K |
2019 |
prot-c-5356_2_3 |
MIF |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
114 association rows across 70 traits (110 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Glutathione S-transferase theta-2B levels |
2e-447 |
rs5751777 |
1 |
GCST90247824 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein GSTT2B levels |
2e-445 |
rs5751777 |
1 |
GCST90943447 |
no MR -> candidate analysis |
| MIF/PARK7 protein level ratio |
1e-391 |
rs4822455 |
1 |
GCST90315447 |
no MR -> candidate analysis |
| MIF/STIP1 protein level ratio |
1e-338 |
rs4822455 |
1 |
GCST90315451 |
no MR -> candidate analysis |
| Glutathione S-transferase theta-1 levels |
2e-330 |
rs2000468 |
1 |
GCST90423466 |
no MR -> candidate analysis |
| MIF/PEBP1 protein level ratio |
3e-298 |
rs4822455 |
1 |
GCST90315448 |
no MR -> candidate analysis |
| HARS1/MIF protein level ratio |
6e-281 |
rs4822455 |
1 |
GCST90315024 |
no MR -> candidate analysis |
| FHIT/MIF protein level ratio |
2e-255 |
rs4822455 |
1 |
GCST90314819 |
no MR -> candidate analysis |
| MIF/S100A4 protein level ratio |
2e-242 |
rs4822455 |
1 |
GCST90315449 |
no MR -> candidate analysis |
| X-16071 levels |
8e-241 |
rs5751777 |
1 |
GCST90245605 |
no MR -> candidate analysis |
| GLOD4/MIF protein level ratio |
1e-184 |
rs4822455 |
1 |
GCST90314939 |
no MR -> candidate analysis |
| MIF/SERPINB1 protein level ratio |
1e-176 |
rs4822455 |
1 |
GCST90315450 |
no MR -> candidate analysis |
| …and 58 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1390 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| systemic-onset juvenile idiopathic arthritis |
0.304 |
— |
established (curated) |
no MR -> candidate analysis |
| cystic fibrosis |
0.608 |
— |
established (curated) |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
2 known modulators (Macrophage migration inhibitory factor) |
| gnomAD constraint |
pLI=1.2e-07, LOEUF=2.16 — LoF-tolerant |
| GWAS Catalog |
112 unique SNPs / 276 rows |
| ClinVar |
162 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1390 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘MIF’ and resolved to ‘Macrophage migration inhibitory factor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 162 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 70 traits by best p-value, aggregated from 114 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P03971 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000240972/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2085/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/MIF — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/MIF — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=MIF%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/MIF — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:48:23 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none