Protein Dossier — MPO (Myeloperoxidase)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Sleep duration |
0.016 |
0.00469 |
6.58e-04 |
Inverse variance weighted |
5 |
trans |
NA |
| Sleep duration |
0.016 |
0.00469 |
6.58e-04 |
Inverse variance weighted |
5 |
trans |
NA |
| Sleep duration |
0.016 |
0.00469 |
6.58e-04 |
Inverse variance weighted |
5 |
trans |
NA |
| Sleep duration |
0.016 |
0.00469 |
6.58e-04 |
Inverse variance weighted |
5 |
cis |
NA |
| Sleep duration |
0.016 |
0.00469 |
6.58e-04 |
Inverse variance weighted |
5 |
trans |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.188 |
0.0733 |
0.0102 |
Inverse variance weighted |
5 |
trans |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.188 |
0.0733 |
0.0102 |
Inverse variance weighted |
5 |
trans |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.188 |
0.0733 |
0.0102 |
Inverse variance weighted |
5 |
trans |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.188 |
0.0733 |
0.0102 |
Inverse variance weighted |
5 |
cis |
NA |
| Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitis |
0.188 |
0.0733 |
0.0102 |
Inverse variance weighted |
5 |
trans |
NA |
| Age at menopause |
0.219 |
0.0933 |
0.0189 |
Inverse variance weighted |
3 |
trans |
NA |
| Age at menopause |
0.219 |
0.0933 |
0.0189 |
Inverse variance weighted |
3 |
trans |
NA |
| …and 392 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2580_83_2 |
Myeloperoxidase |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
139 association rows across 64 traits (136 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating MPO levels |
3e-475 |
rs34097845 |
7 |
GCST90859948 |
no MR -> candidate analysis |
| MPO protein levels |
2e-307 |
rs34097845 |
6 |
GCST90469937 |
no MR -> candidate analysis |
| Hematological traits (multi-trait analysis) |
4e-178 |
rs34097845 |
1 |
GCST90838669 |
no MR -> candidate analysis |
| Monocyte percentage (UKB data field 30190) |
2e-158 |
rs34097845 |
2 |
GCST90468091 |
no MR -> candidate analysis |
| Myeloperoxidase levels |
4e-134 |
rs34097845 |
5 |
GCST90012031 |
no MR -> candidate analysis |
| Monocyte count |
3e-124 |
rs34097845 |
8 |
GCST90002340 |
no MR -> candidate analysis |
| Monocyte count (UKB data field 30130) |
1e-102 |
rs34097845 |
3 |
GCST90468090 |
no MR -> candidate analysis |
| AZU1/MPO protein level ratio |
9e-81 |
rs56378716 |
1 |
GCST90313425 |
no MR -> candidate analysis |
| CEACAM6 protein levels |
5e-76 |
rs56378716 |
2 |
GCST90468697 |
no MR -> candidate analysis |
| Monocyte percentage of white cells |
7e-71 |
rs34097845 |
5 |
GCST90002394 |
no MR -> candidate analysis |
| Neutrophil side scatter |
3e-64 |
rs119468010 |
2 |
GCST90281222 |
no MR -> candidate analysis |
| Granulocyte percentage of myeloid white cells |
9e-57 |
rs34097845 |
1 |
GCST004608 |
no MR -> candidate analysis |
| …and 52 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1665 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| myeloperoxidase deficiency |
0.874 |
— |
established (curated) |
no MR -> candidate analysis |
| Alzheimer disease type 1 |
0.798 |
— |
established (curated) |
no MR -> candidate analysis |
| Alzheimer disease |
0.195 |
— |
established (curated) |
no MR -> candidate analysis |
| Abnormality of the skeletal system |
0.22 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
1 known modulators (Myeloperoxidase) |
| gnomAD constraint |
pLI=2.1e-16, LOEUF=1.02 — LoF-tolerant |
| GWAS Catalog |
105 unique SNPs / 212 rows |
| ClinVar |
177 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1665 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘MPO’ and resolved to ‘Myeloperoxidase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 177 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 64 traits by best p-value, aggregated from 139 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P05164 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000005381/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2439/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/MPO — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/MPO — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=MPO%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/MPO — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:51:25 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none