MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Cancer code self-reported: prostate cancer | -0.277 | 0.0387 | 7.81e-13 | Wald ratio | 1 | cis | 1 |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | -0.282 | 0.0408 | 4.75e-12 | Wald ratio | 1 | cis | 1 |
| HOMA-B | -0.0102 | 0.00356 | 0.00427 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | -0.0286 | 0.0106 | 0.00696 | Wald ratio | 1 | cis | NA |
| Weight | -0.00583 | 0.00221 | 0.00836 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression | -0.15 | 0.0572 | 0.00855 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0096 | 0.0037 | 0.00952 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.0257 | 0.0108 | 0.018 | Wald ratio | 1 | cis | NA |
| HOMA-IR | -0.0101 | 0.00438 | 0.0213 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | -0.0519 | 0.0228 | 0.0228 | Wald ratio | 1 | cis | NA |
| Iron | -0.0238 | 0.0106 | 0.0244 | Wald ratio | 1 | cis | NA |
| Coronary heart disease | 0.0217 | 0.00969 | 0.025 | Wald ratio | 1 | cis | NA |
| …and 104 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
79 association rows across 33 traits (69 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating MSMB levels | 7e-5547 | rs10993994 | 2 | GCST90860651 | no MR -> candidate analysis |
| Beta-microseminoprotein levels | 2e-2145 | rs10993994 | 2 | GCST90246712 | no MR -> candidate analysis |
| Beta-microseminoprotein levels (MSMB.10620.21.3) | 4e-589 | rs10993994 | 2 | GCST90240438 | no MR -> candidate analysis |
| Prostate-specific antigen levels | 4e-436 | rs10993994 | 5 | GCST90461907 | no MR -> candidate analysis |
| Blood protein levels | 1e-329 | rs11006489 | 1 | GCST006585 | no MR -> candidate analysis |
| Prostate cancer | 1e-325 | rs10993994 | 36 | GCST90274713 | MR: beta=-0.277, p=7.81e-13 (cis) |
| MSMB protein levels | 1e-101 | rs113749034 | 3 | GCST90469949 | no MR -> candidate analysis |
| Cerebrospinal fluid protein MSMB levels | 1e-79 | rs10993994 | 1 | GCST90944826 | no MR -> candidate analysis |
| PSP94 plasma levels | 8e-49 | rs10993994 | 1 | GCST90085769 | no MR -> candidate analysis |
| Secretory phospholipase A2 receptor protein levels (SomaScan | 7e-38 | rs10993994 | 1 | GCST90438883 | no MR -> candidate analysis |
| Circulating CRISP2 levels | 2e-17 | rs10993994 | 1 | GCST90860530 | no MR -> candidate analysis |
| CRISP2 protein levels | 3e-17 | rs10993994 | 1 | GCST90468865 | no MR -> candidate analysis |
| …and 21 more traits (see JSON) |
Top diseases by Open Targets association (of 310 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| prostate carcinoma | 0.854 | — | common-variant locus | no MR -> candidate analysis |
| prostate cancer | 0.802 | — | common-variant locus | MR: beta=-0.277, p=7.81e-13 (cis) |
| ovarian cancer | 0.538 | — | common-variant locus | MR: beta=0.0214, p=0.187 (cis) |
| cancer | 0.549 | — | common-variant locus | MR: beta=-0.277, p=7.81e-13 (cis) |
| endometrial cancer | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| gastric cancer | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| non-Hodgkin lymphoma | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| breast carcinoma | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| lung cancer | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| hepatocellular carcinoma | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| biliary tract cancer | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| exocrine pancreatic carcinoma | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| colorectal cancer | 0.538 | — | common-variant locus | no MR -> candidate analysis |
| esophageal cancer | 0.538 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.00033, LOEUF=1.62 — LoF-tolerant |
| GWAS Catalog | 43 unique SNPs / 86 rows |
| ClinVar | 91 records; 13 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 310 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘MSMB’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 91 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 33 traits by best p-value, aggregated from 79 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P08118 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000263639/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/MSMB — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/MSMB — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=MSMB%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/MSMB — GWAS Catalog search API (live; release not exposed)