Protein Dossier — MSR1 (Macrophage scavenger receptor types I and II)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Myocardial infarction |
-0.129 |
0.0368 |
4.76e-04 |
Wald ratio |
1 |
trans |
NA |
| Coronary heart disease |
-0.111 |
0.0334 |
8.64e-04 |
Wald ratio |
1 |
trans |
NA |
| Amyotrophic lateral sclerosis |
-0.197 |
0.0604 |
0.00113 |
Wald ratio |
1 |
trans |
NA |
| Eczema |
0.178 |
0.0591 |
0.00266 |
Wald ratio |
1 |
trans |
NA |
| Years of schooling |
-0.0394 |
0.0131 |
0.0027 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation |
0.141 |
0.048 |
0.0033 |
Wald ratio |
1 |
trans |
NA |
| Chronic kidney disease |
0.145 |
0.0526 |
0.00596 |
Wald ratio |
1 |
trans |
NA |
| Forced vital capacity (FVC) |
-0.0177 |
0.0065 |
0.00649 |
Wald ratio |
1 |
trans |
NA |
| LDL cholesterol |
-0.0496 |
0.0184 |
0.00701 |
Wald ratio |
1 |
trans |
NA |
| Sodium in urine |
0.0197 |
0.0078 |
0.0115 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: deep venous thrombosis (dvt) |
-0.165 |
0.0666 |
0.0133 |
Wald ratio |
1 |
trans |
NA |
| Heel bone mineral density (BMD) T-score automated |
0.0251 |
0.0103 |
0.0143 |
Wald ratio |
1 |
trans |
NA |
| …and 100 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3684_78_3 |
Macrophage scavenger receptor |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
147 association rows across 90 traits (112 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating MSR1 levels |
7e-323 |
rs76393968 |
9 |
GCST90859674 |
no MR -> candidate analysis |
| MSR1 protein levels |
2e-246 |
rs10103856 |
6 |
GCST90469950 |
no MR -> candidate analysis |
| C1QTNF5 protein levels |
5e-205 |
rs73665255 |
8 |
GCST90468489 |
no MR -> candidate analysis |
| LGALS3BP protein levels |
5e-187 |
rs73665255 |
7 |
GCST90469760 |
no MR -> candidate analysis |
| Galectin-3-binding protein levels |
9e-172 |
rs41341748 |
4 |
GCST90247672 |
no MR -> candidate analysis |
| Macrophage scavenger receptor types I and II levels |
4e-119 |
rs41341748 |
6 |
GCST90248385 |
no MR -> candidate analysis |
| FOLR2/MSR1 protein level ratio |
1e-76 |
rs17583220 |
1 |
GCST90314866 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein MSR1 levels |
9e-76 |
rs41341748 |
1 |
GCST90944440 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein C1QTNF5 levels |
3e-44 |
rs41341748 |
1 |
GCST90944136 |
no MR -> candidate analysis |
| ITGBL1 protein levels |
3e-32 |
rs41341748 |
2 |
GCST90469648 |
no MR -> candidate analysis |
| PTX3 protein levels |
3e-32 |
rs41341748 |
2 |
GCST90470392 |
no MR -> candidate analysis |
| MMP3 protein levels |
6e-31 |
rs41341748 |
1 |
GCST90469920 |
no MR -> candidate analysis |
| …and 78 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 435 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| Barrett esophagus |
0.63 |
— |
established (curated) |
no MR -> candidate analysis |
| ovarian cancer |
0.641 |
— |
established (curated) |
MR: beta=-0.192, p=0.248 (trans) |
| esophageal adenocarcinoma |
0.547 |
— |
established (curated) |
no MR -> candidate analysis |
| alcohol drinking |
0.548 |
— |
common-variant locus |
no MR -> candidate analysis |
| urolithiasis |
0.548 |
— |
common-variant locus |
no MR -> candidate analysis |
| cannabis dependence |
0.542 |
— |
common-variant locus |
no MR -> candidate analysis |
| keloid |
0.523 |
— |
common-variant locus |
no MR -> candidate analysis |
| cervical carcinoma |
0.492 |
— |
common-variant locus |
no MR -> candidate analysis |
| fungal infectious disease |
0.495 |
— |
common-variant locus |
no MR -> candidate analysis |
| sialadenitis |
0.492 |
— |
common-variant locus |
no MR -> candidate analysis |
| carcinoma of esophagus |
0.486 |
— |
established (curated) |
no MR -> candidate analysis |
| bipolar disorder |
0.478 |
— |
common-variant locus |
MR: beta=0.0814, p=0.348 (trans) |
| muscle cramp |
0.424 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary artery disorder |
0.404 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.396 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Macrophage scavenger receptor types I and II) |
| gnomAD constraint |
pLI=1.9e-20, LOEUF=1.41 — LoF-tolerant |
| GWAS Catalog |
117 unique SNPs / 185 rows |
| ClinVar |
239 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 435 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘MSR1’ and resolved to ‘Macrophage scavenger receptor types I and II’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 239 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 90 traits by best p-value, aggregated from 147 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P21757 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000038945/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5811/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/MSR1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/MSR1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=MSR1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/MSR1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:52:28 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none