Protein Dossier — NCR1 (Natural cytotoxicity triggering receptor 1)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Clear cell ovarian cancer |
-0.427 |
0.194 |
0.0272 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
0.0748 |
0.0489 |
0.127 |
Wald ratio |
1 |
cis |
NA |
| Depressive symptoms |
0.0276 |
0.0193 |
0.153 |
Wald ratio |
1 |
cis |
NA |
| Intracranial volume |
1.84e+04 |
1.3e+04 |
0.158 |
Wald ratio |
1 |
cis |
NA |
| Lumbar spine bone mineral density |
-0.0627 |
0.0505 |
0.215 |
Wald ratio |
1 |
cis |
NA |
| Amyotrophic lateral sclerosis |
0.108 |
0.0895 |
0.226 |
Wald ratio |
1 |
cis |
NA |
| Femoral neck bone mineral density |
-0.0556 |
0.048 |
0.246 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
46.2 |
42.1 |
0.273 |
Wald ratio |
1 |
cis |
NA |
| Myocardial infarction |
0.0586 |
0.0547 |
0.284 |
Wald ratio |
1 |
cis |
NA |
| Squamous cell lung cancer |
-0.176 |
0.168 |
0.295 |
Wald ratio |
1 |
cis |
NA |
| Lung adenocarcinoma |
0.146 |
0.147 |
0.322 |
Wald ratio |
1 |
cis |
NA |
| Birth weight |
-0.0163 |
0.0193 |
0.399 |
Wald ratio |
1 |
cis |
NA |
| …and 1 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-5104_57_3 |
NKp46 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
41 association rows across 23 traits (39 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating FCAR levels |
3e-1287 |
rs59090680 |
1 |
GCST90860714 |
no MR -> candidate analysis |
| Circulating NCR1 levels (id: OID01007_OID20566) |
2e-341 |
rs2278427 |
4 |
GCST90860233 |
no MR -> candidate analysis |
| Circulating NCR1 levels (id: OID00816_OID20566) |
1e-337 |
rs2278427 |
4 |
GCST90860146 |
no MR -> candidate analysis |
| FCAR protein levels |
7e-178 |
rs9789251 |
2 |
GCST90469197 |
no MR -> candidate analysis |
| NCR1 protein levels |
1e-144 |
rs11880295 |
2 |
GCST90470009 |
no MR -> candidate analysis |
| KIR2DS4 protein levels |
1e-119 |
rs622941 |
3 |
GCST90469686 |
no MR -> candidate analysis |
| Natural cytotoxicity triggering receptor 1 levels |
2e-75 |
rs2278428 |
3 |
GCST90248750 |
no MR -> candidate analysis |
| KIR2DL2 protein levels |
3e-51 |
rs58244710 |
3 |
GCST90469684 |
no MR -> candidate analysis |
| KIR2DL3 protein levels |
1e-46 |
rs62124577 |
2 |
GCST90469685 |
no MR -> candidate analysis |
| Immunoglobulin alpha Fc receptor levels |
5e-46 |
rs57490427 |
1 |
GCST90059957 |
no MR -> candidate analysis |
| Natural cytotoxicity triggering receptor 1 (analyte X5104.57 |
2e-34 |
rs140786877 |
1 |
GCST90426248 |
no MR -> candidate analysis |
| Serum levels of protein NCR1 |
9e-33 |
rs2278427 |
1 |
GCST90090153 |
no MR -> candidate analysis |
| …and 11 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 398 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| alcohol drinking |
0.263 |
— |
common-variant locus |
no MR -> candidate analysis |
| urolithiasis |
0.263 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Natural cytotoxicity triggering receptor 1) |
| gnomAD constraint |
pLI=3.6e-10, LOEUF=1.25 — LoF-tolerant |
| GWAS Catalog |
133 unique SNPs / 273 rows |
| ClinVar |
247 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 398 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘NCR1’ and resolved to ‘Natural cytotoxicity triggering receptor 1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 247 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 23 traits by best p-value, aggregated from 41 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/O76036 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000189430/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL6066290/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/NCR1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NCR1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NCR1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NCR1 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T03:56:53 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none