MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Body mass index (BMI) | -0.102 | 0.0163 | 3.92e-10 | Wald ratio | 1 | cis | NA |
| Sodium in urine | 0.0901 | 0.016 | 1.88e-08 | Wald ratio | 1 | cis | NA |
| Weight | -0.0759 | 0.0144 | 1.30e-07 | Wald ratio | 1 | cis | NA |
| Triglycerides | -0.0791 | 0.0223 | 3.92e-04 | Wald ratio | 1 | cis | NA |
| Years of schooling | -0.0878 | 0.027 | 0.00115 | Wald ratio | 1 | cis | NA |
| Body fat | -0.1 | 0.0311 | 0.00129 | Wald ratio | 1 | cis | NA |
| Lung adenocarcinoma | 0.538 | 0.175 | 0.00211 | Wald ratio | 1 | cis | NA |
| Age at menarche | 0.115 | 0.0381 | 0.0026 | Wald ratio | 1 | cis | NA |
| Creatinine (enzymatic) in urine | 0.044 | 0.0156 | 0.00476 | Wald ratio | 1 | cis | NA |
| Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis) | 0.107 | 0.0419 | 0.0103 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0572 | 0.0241 | 0.0176 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.138 | 0.0586 | 0.019 | Wald ratio | 1 | cis | NA |
| …and 107 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
258 association rows across 133 traits (215 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Educational attainment | 2e-71 | rs34305371 | 11 | GCST90105038 | no MR -> candidate analysis |
| Principal component-derived dietary pattern 1 | 3e-48 | rs66495454 | 1 | GCST90133006 | no MR -> candidate analysis |
| Smoking initiation | 1e-47 | rs12737564 | 1 | GCST90243985 | no MR -> candidate analysis |
| Neuronal growth regulator 1 levels | 2e-45 | rs1194278 | 3 | GCST90248636 | no MR -> candidate analysis |
| Educational attainment (MTAG) | 8e-41 | rs34305371 | 3 | GCST006571 | no MR -> candidate analysis |
| Educational attainment (years of education) | 1e-39 | rs34305371 | 6 | GCST006442 | no MR -> candidate analysis |
| Insomnia | 1e-31 | rs1620977 | 21 | GCST90131901 | no MR -> candidate analysis |
| CAMSIS occupational score (MTAG) | 9e-28 | rs34305371 | 3 | GCST90492678 | no MR -> candidate analysis |
| Cognitive performance (MTAG) | 5e-27 | rs12128707 | 2 | GCST006570 | no MR -> candidate analysis |
| SIOPS occupational score (MTAG) | 2e-26 | rs34305371 | 3 | GCST90492679 | no MR -> candidate analysis |
| ISEI occupational score (MTAG) | 2e-26 | rs34305371 | 3 | GCST90492677 | no MR -> candidate analysis |
| Frailty (Factor 5 - Poorer Cognition) | 3e-25 | rs12128707 | 1 | GCST90624051 | no MR -> candidate analysis |
| …and 121 more traits (see JSON) |
Top diseases by Open Targets association (of 229 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| major depressive disorder | 0.848 | — | common-variant locus | MR: beta=-0.215, p=0.141 (cis) |
| intelligence | 0.865 | — | common-variant locus | MR: beta=-0.174, p=0.0438 (cis) |
| Abnormality of the skeletal system | 0.855 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.828 | — | common-variant locus | no MR -> candidate analysis |
| autism spectrum disorder | 0.757 | — | common-variant locus | no MR -> candidate analysis |
| attention deficit-hyperactivity disorder | 0.759 | — | common-variant locus | no MR -> candidate analysis |
| hair color | 0.748 | — | common-variant locus | no MR -> candidate analysis |
| bipolar disorder | 0.732 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.718 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.725 | — | common-variant locus | no MR -> candidate analysis |
| schizophrenia | 0.709 | — | common-variant locus | MR: beta=-0.1, p=0.167 (cis) |
| overnutrition | 0.721 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.685 | — | common-variant locus | no MR -> candidate analysis |
| smoking behavior | 0.66 | — | common-variant locus | no MR -> candidate analysis |
| insomnia | 0.66 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.415 — LoF-INTOLERANT |
| GWAS Catalog | 182 unique SNPs / 446 rows |
| ClinVar | 105 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 229 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘NEGR1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 105 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 133 traits by best p-value, aggregated from 258 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q7Z3B1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000172260/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/NEGR1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NEGR1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NEGR1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NEGR1 — GWAS Catalog search API (live; release not exposed)