MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Pulse rate | -0.101 | 0.0246 | 3.79e-05 | Wald ratio | 1 | cis | NA |
| Triglycerides | -0.107 | 0.029 | 2.27e-04 | Wald ratio | 1 | cis | NA |
| Weight | -0.0406 | 0.0123 | 9.97e-04 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | -0.0535 | 0.0181 | 0.00316 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0403 | 0.014 | 0.00396 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.454 | 0.159 | 0.00419 | Wald ratio | 1 | cis | NA |
| Large vessel disease | -0.575 | 0.221 | 0.00913 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: anxiety or panic attacks | 0.245 | 0.0953 | 0.0102 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: iron deficiency anaemia | 0.354 | 0.138 | 0.0102 | Wald ratio | 1 | cis | NA |
| HbA1C | 0.0496 | 0.0206 | 0.0161 | Wald ratio | 1 | cis | NA |
| Thyroid cancer | -1.2 | 0.544 | 0.0274 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | -0.0313 | 0.0143 | 0.0289 | Wald ratio | 1 | cis | NA |
| …and 81 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
88 association rows across 66 traits (79 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 1e-64 | rs117092649 | 1 | GCST90321120 | no MR -> candidate analysis |
| Neogenin levels | 3e-57 | rs62016793 | 2 | GCST90248639 | no MR -> candidate analysis |
| Educational attainment | 1e-24 | rs10468056 | 1 | GCST90105038 | no MR -> candidate analysis |
| NEO1 protein levels | 2e-22 | rs34858546 | 1 | GCST90470029 | no MR -> candidate analysis |
| Trunk fat mass (UKB data field 23128) | 4e-20 | rs7171864 | 1 | GCST90468180 | no MR -> candidate analysis |
| Serum levels of protein NEO1 | 1e-19 | rs10467948 | 1 | GCST90090371 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 1e-19 | rs8025665 | 1 | GCST90095129 | no MR -> candidate analysis |
| Mean corpuscular hemoglobin | 2e-19 | rs150712926 | 5 | GCST90002322 | no MR -> candidate analysis |
| Leg fat percentage right (UKB data field 23111) | 7e-19 | rs2415142 | 1 | GCST90468175 | no MR -> candidate analysis |
| Hip circumference (UKB data field 49) | 4e-17 | rs7171864 | 1 | GCST90468170 | no MR -> candidate analysis |
| Appendicular lean mass | 1e-16 | rs2680338 | 1 | GCST90000025 | no MR -> candidate analysis |
| Metabolic syndrome | 1e-16 | rs8039418 | 1 | GCST90444487 | no MR -> candidate analysis |
| …and 54 more traits (see JSON) |
Top diseases by Open Targets association (of 212 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| dentures | 0.758 | — | common-variant locus | no MR -> candidate analysis |
| dental caries | 0.678 | — | common-variant locus | no MR -> candidate analysis |
| Varicose veins | 0.548 | — | common-variant locus | MR: beta=-0.454, p=0.00419 (cis) |
| self-injurious ideation | 0.539 | — | common-variant locus | no MR -> candidate analysis |
| atrial fibrillation | 0.515 | — | common-variant locus | MR: beta=0.143, p=0.221 (cis) |
| Alzheimer disease | 0.431 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.431 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.328 | — | common-variant locus | no MR -> candidate analysis |
| urolithiasis | 0.328 | — | common-variant locus | no MR -> candidate analysis |
| skin disorder | 0.306 | — | common-variant locus | no MR -> candidate analysis |
| subcutaneous tissue disorder | 0.306 | — | common-variant locus | no MR -> candidate analysis |
| methicillin-resistant staphylococcus aureus infectious disease | 0.242 | — | common-variant locus | no MR -> candidate analysis |
| anti-GAD65 autoimmune neurological syndromes | 0.237 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.214 | — | common-variant locus | no MR -> candidate analysis |
Of the 14 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.85, LOEUF=0.487 — LoF-tolerant |
| GWAS Catalog | 89 unique SNPs / 178 rows |
| ClinVar | 302 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 212 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘NEO1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 302 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 66 traits by best p-value, aggregated from 88 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q92859 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000067141/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/NEO1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NEO1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NEO1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NEO1 — GWAS Catalog search API (live; release not exposed)