MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) | 1 | 0.254 | 7.74e-05 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Diabetes related eye disease | 0.29 | 0.0891 | 0.00116 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: bone disorder | 0.386 | 0.136 | 0.00468 | Wald ratio | 1 | cis | NA |
| Forced expiratory volume in 1-second (FEV1) | -0.0204 | 0.00796 | 0.0103 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | 0.0308 | 0.0136 | 0.0234 | Wald ratio | 1 | cis | NA |
| Forced vital capacity (FVC) | -0.0169 | 0.00755 | 0.0253 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N81 Female genital prolapse | -0.211 | 0.0959 | 0.0279 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M54 Dorsalgia | 0.131 | 0.0629 | 0.0378 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: migraine | 0.0977 | 0.0483 | 0.0431 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R14 Flatulence and related conditions | 0.477 | 0.256 | 0.0628 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I84 Haemorrhoids | -0.117 | 0.0668 | 0.0793 | Wald ratio | 1 | cis | NA |
| Endometrioid ovarian cancer | 0.211 | 0.133 | 0.113 | Wald ratio | 1 | cis | NA |
| …and 59 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
167 association rows across 88 traits (142 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Height | 1e-300 | rs1401796 | 32 | GCST90245843 | no MR -> candidate analysis |
| Noggin levels | 3e-170 | rs76164057 | 2 | GCST90248705 | no MR -> candidate analysis |
| Standing height (UKB data field 50) | 3e-64 | rs9908159 | 4 | GCST90468178 | no MR -> candidate analysis |
| Body size or adipose distribution (multivariate analysis) | 1e-51 | rs1401795 | 1 | GCST90624105 | no MR -> candidate analysis |
| Height (baseline) | 2e-50 | rs963292 | 9 | GCST90565843 | no MR -> candidate analysis |
| height (mean, inv-normal transformed) | 2e-49 | rs12602666 | 1 | GCST90479635 | no MR -> candidate analysis |
| Height (maximum, inv-normal transformed) | 2e-49 | rs12602666 | 1 | GCST90479634 | no MR -> candidate analysis |
| height (minimum, inv-normal transformed) | 1e-47 | rs12602666 | 1 | GCST90479636 | no MR -> candidate analysis |
| Refractive error | 2e-45 | rs1986023 | 5 | GCST90841193 | no MR -> candidate analysis |
| Serum levels of protein NOG | 1e-40 | rs35250090 | 2 | GCST90090292 | no MR -> candidate analysis |
| Body shape phenotype PC2 | 2e-39 | rs963292 | 2 | GCST90832990 | no MR -> candidate analysis |
| Peak expiratory flow | 9e-34 | rs62074819 | 2 | GCST90244095 | no MR -> candidate analysis |
| …and 76 more traits (see JSON) |
Top diseases by Open Targets association (of 2471 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| proximal symphalangism 1A | 0.922 | — | established (curated) | no MR -> candidate analysis |
| brachydactyly type B2 | 0.855 | — | established (curated) | no MR -> candidate analysis |
| multiple synostoses syndrome 1 | 0.843 | — | established (curated) | no MR -> candidate analysis |
| tarsal-carpal coalition syndrome | 0.803 | — | established (curated) | no MR -> candidate analysis |
| stapes ankylosis with broad thumbs and toes | 0.788 | — | established (curated) | no MR -> candidate analysis |
| multiple synostoses syndrome | 0.608 | — | established (curated) | no MR -> candidate analysis |
| proximal symphalangism | 0.608 | — | established (curated) | no MR -> candidate analysis |
| hereditary disease | 0.81 | — | established (curated) | no MR -> candidate analysis |
| Progressive visual loss | 0.526 | — | common-variant locus | no MR -> candidate analysis |
| amyotrophic lateral sclerosis | 0.517 | — | common-variant locus | MR: beta=-0.107, p=0.177 (cis) |
| placenta praevia | 0.51 | — | common-variant locus | no MR -> candidate analysis |
| Bethlem myopathy 2 | 0.438 | — | established (curated) | no MR -> candidate analysis |
| ventral hernia | 0.408 | — | common-variant locus | no MR -> candidate analysis |
| cleft lip | 0.385 | — | common-variant locus | no MR -> candidate analysis |
| Micrognathia | 0.365 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.353 — LoF-INTOLERANT |
| GWAS Catalog | 101 unique SNPs / 203 rows |
| ClinVar | 266 records; 5 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 2471 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘NOG’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 266 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 88 traits by best p-value, aggregated from 167 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q13253 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000183691/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/NOG — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NOG — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NOG%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NOG — GWAS Catalog search API (live; release not exposed)