MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Small vessel disease | -0.57 | 0.184 | 0.00194 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M23 Internal derangement of knee | 0.208 | 0.068 | 0.0022 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gastro-oesophageal reflux (gord) or gastric reflux | 0.148 | 0.0516 | 0.00413 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K40 Inguinal hernia | 0.178 | 0.0637 | 0.00522 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] | 0.19 | 0.0742 | 0.0103 | Wald ratio | 1 | cis | NA |
| Fasting glucose | -0.0425 | 0.0177 | 0.0162 | Wald ratio | 1 | cis | NA |
| Gallbladder cancer | 2.78 | 1.17 | 0.0176 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K20 Oesophagitis | 0.228 | 0.101 | 0.0234 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | 0.0955 | 0.043 | 0.0263 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Cataract | -0.17 | 0.0809 | 0.036 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | 0.143 | 0.0699 | 0.0412 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis | 0.197 | 0.0972 | 0.0426 | Wald ratio | 1 | cis | NA |
| …and 97 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
47 association rows across 33 traits (35 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| NRP2 protein levels | 1e-135 | rs16837641 | 9 | GCST90470086 | no MR -> candidate analysis |
| Circulating NRP2 levels | 3e-132 | rs16837641 | 5 | GCST90859655 | no MR -> candidate analysis |
| Neuropilin-2 levels | 2e-25 | rs16837641 | 1 | GCST90248733 | no MR -> candidate analysis |
| Type 2 diabetes | 3e-20 | rs3771003 | 1 | GCST90134620 | MR: beta=0.0946, p=0.187 (cis) |
| Circulating SEMA3F levels | 2e-15 | rs2160327 | 1 | GCST90860355 | no MR -> candidate analysis |
| ADAM23 protein levels | 3e-15 | rs10188991 | 2 | GCST90468219 | no MR -> candidate analysis |
| Neuropilin-2 levels (NRP2.6590.54.3) | 1e-14 | rs16837641 | 1 | GCST90242094 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 2e-14 | rs863707 | 1 | GCST90095129 | no MR -> candidate analysis |
| GLIPR1 protein levels | 3e-14 | rs183879700 | 1 | GCST90469357 | no MR -> candidate analysis |
| Meningitis (PheCode 320) | 3e-12 | rs543029525 | 1 | GCST90479995 | no MR -> candidate analysis |
| SEMA3F protein levels | 3e-12 | rs2160327 | 1 | GCST90470570 | no MR -> candidate analysis |
| Male-pattern baldness | 7e-11 | rs1861386 | 1 | GCST007020 | no MR -> candidate analysis |
| …and 21 more traits (see JSON) |
Top diseases by Open Targets association (of 1672 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| esophageal disorder | 0.666 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.616 | — | common-variant locus | no MR -> candidate analysis |
| glaucoma | 0.542 | — | common-variant locus | MR: beta=-0.112, p=0.341 (cis) |
| femoral neck fracture | 0.542 | — | common-variant locus | no MR -> candidate analysis |
| Jaundice | 0.537 | — | common-variant locus | no MR -> candidate analysis |
| gastroesophageal reflux disease | 0.536 | — | common-variant locus | no MR -> candidate analysis |
| flatulence | 0.534 | — | common-variant locus | no MR -> candidate analysis |
| osteomyelitis | 0.51 | — | common-variant locus | no MR -> candidate analysis |
| food allergy | 0.506 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.491 | — | common-variant locus | no MR -> candidate analysis |
| infectious meningitis | 0.482 | — | common-variant locus | no MR -> candidate analysis |
| cholelithiasis | 0.482 | — | common-variant locus | MR: beta=-0.0707, p=0.449 (cis) |
| hereditary disease | 0.438 | — | established (curated) | no MR -> candidate analysis |
| parasitic infectious disease | 0.323 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.274 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (NRP2-VEGA) |
| gnomAD constraint | pLI=8.5e-05, LOEUF=0.594 — LoF-tolerant |
| GWAS Catalog | 120 unique SNPs / 282 rows |
| ClinVar | 430 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 1672 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘NRP2’ and resolved to ‘NRP2-VEGA’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 430 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 33 traits by best p-value, aggregated from 47 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q99435 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000118257/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5482995/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/NRP2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NRP2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NRP2%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=NRP2 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/NRP2 — GWAS Catalog search API (live; release not exposed)