MR feasibility tier: C — No plasma pQTL found (accession + symbol match). Standard plasma pQTL MR is not currently feasible; gene-level genetic evidence below is the honest preview.
None in the EpiGraphDB pQTL resource. Absence of an estimate is not evidence of no effect.
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
269 association rows across 168 traits (175 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Neurotrimin levels | 4e-244 | rs2511504 | 3 | GCST90248752 | no MR -> candidate analysis |
| Serum levels of protein NTM | 7e-97 | rs2511781 | 3 | GCST90090196 | no MR -> candidate analysis |
| Opioid-binding protein/cell adhesion molecule levels | 3e-71 | rs2511504 | 2 | GCST90248770 | no MR -> candidate analysis |
| Blood protein levels | 2e-58 | rs2511504 | 2 | GCST006585 | no MR -> candidate analysis |
| Refractive error | 2e-40 | rs1790165 | 3 | GCST90841196 | no MR -> candidate analysis |
| Lung function (FEV1/FVC) | 7e-28 | rs4491239 | 2 | GCST007080 | no MR -> candidate analysis |
| Smoking initiation | 2e-27 | rs617267 | 14 | GCST90243985 | no MR -> candidate analysis |
| FEV1 FVC ratio Z score (UKB data field 20258) | 7e-26 | rs7118465 | 1 | GCST90468165 | no MR -> candidate analysis |
| FEV1/FVC ratio | 1e-22 | rs10466626 | 1 | GCST90705072 | no MR -> candidate analysis |
| Chronic obstructive pulmonary disease liability (machine lea | 5e-21 | rs6590623 | 1 | GCST90244098 | no MR -> candidate analysis |
| GLIPR1 protein levels | 8e-20 | rs554309481 | 2 | GCST90469357 | no MR -> candidate analysis |
| Pre-treatment viral load in HIV-1 infection | 1e-16 | rs78430868 | 1 | GCST008758 | no MR -> candidate analysis |
| …and 156 more traits (see JSON) |
Top diseases by Open Targets association (of 157 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| smoking initiation | 0.681 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.634 | — | common-variant locus | no MR -> candidate analysis |
| health study participation | 0.625 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.605 | — | common-variant locus | no MR -> candidate analysis |
| chronic intestinal vascular insufficiency | 0.587 | — | common-variant locus | no MR -> candidate analysis |
| uterine polyp | 0.523 | — | common-variant locus | no MR -> candidate analysis |
| refractive error | 0.521 | — | common-variant locus | no MR -> candidate analysis |
| duodenitis | 0.51 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.508 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.502 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.495 | — | common-variant locus | no MR -> candidate analysis |
| Hypermetropia | 0.495 | — | common-variant locus | no MR -> candidate analysis |
| response to beta blocker | 0.492 | — | common-variant locus | no MR -> candidate analysis |
| acute pancreatitis | 0.492 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.485 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.99, LOEUF=0.491 — LoF-INTOLERANT |
| GWAS Catalog | 152 unique SNPs / 389 rows |
| ClinVar | 144 records; 6 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 157 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘NTM’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 144 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 168 traits by best p-value, aggregated from 269 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q6ZSK4 — UniProt release 2026_02 (10-June-2026)phenome: https://platform.opentargets.org/target/ENSG00000182667/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/NTM — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NTM — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NTM%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NTM — GWAS Catalog search API (live; release not exposed)