MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Diagnoses - main ICD10: B37 Candidiasis | 0.528 | 0.192 | 0.00603 | Wald ratio | 1 | cis | NA |
| Putamen volume | 42.4 | 16.1 | 0.00826 | Wald ratio | 1 | cis | NA |
| Cough on most days | 0.0768 | 0.0312 | 0.0137 | Wald ratio | 1 | cis | NA |
| Systemic lupus erythematosus | -0.289 | 0.128 | 0.0241 | Wald ratio | 1 | cis | NA |
| Femoral neck bone mineral density | 0.0448 | 0.0208 | 0.031 | Wald ratio | 1 | cis | NA |
| Systolic blood pressure automated reading | 0.0144 | 0.0067 | 0.0312 | Wald ratio | 1 | cis | NA |
| LDL cholesterol | -0.0297 | 0.0138 | 0.0316 | Wald ratio | 1 | cis | NA |
| Lung adenocarcinoma | -0.166 | 0.0782 | 0.0333 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level | 0.442 | 0.211 | 0.0357 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.014 | 0.0067 | 0.0361 | Wald ratio | 1 | cis | NA |
| Fasting proinsulin | -0.0363 | 0.019 | 0.0563 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypertrophic cardiomyopathy (hcm or hocm) | 0.554 | 0.291 | 0.0567 | Wald ratio | 1 | cis | NA |
| …and 104 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
130 association rows across 79 traits (94 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Netrin-1 levels | 1e-184 | rs9897200 | 7 | GCST90248643 | no MR -> candidate analysis |
| Serum levels of protein NTN1 | 9e-84 | rs10468483 | 4 | GCST90090447 | no MR -> candidate analysis |
| Blood protein levels | 5e-53 | rs72809988 | 2 | GCST006585 | no MR -> candidate analysis |
| Netrin-1 levels (NTN1.6649.51.3) | 2e-52 | rs72809988 | 2 | GCST90242047 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 2e-40 | rs80100171 | 1 | GCST90095129 | no MR -> candidate analysis |
| Netrin-1 (analyte X6649.51) levels | 1e-39 | rs9894560 | 1 | GCST90426808 | no MR -> candidate analysis |
| Estimated bone mineral density | 5e-39 | rs56235417 | 4 | GCST90726625 | no MR -> candidate analysis |
| Height | 7e-39 | rs3744656 | 3 | GCST90245848 | no MR -> candidate analysis |
| Heel bone mineral density | 1e-36 | rs56235417 | 10 | GCST006979 | MR: beta=-0.0121, p=0.155 (cis) |
| Netrin-1 (analyte X9013.60) levels | 3e-34 | rs9894560 | 1 | GCST90427601 | no MR -> candidate analysis |
| Whole brain restricted directional diffusion (multivariate a | 1e-23 | rs56235417 | 1 | GCST90131905 | no MR -> candidate analysis |
| Unsupervised deep imaging phenotypes (UDIP-FA) | 4e-23 | rs1107361 | 2 | GCST90860937 | no MR -> candidate analysis |
| …and 67 more traits (see JSON) |
Top diseases by Open Targets association (of 1462 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| mirror movements 4 | 0.816 | — | established (curated) | no MR -> candidate analysis |
| cleft palate | 0.613 | — | established (curated) | no MR -> candidate analysis |
| cleft lip | 0.613 | — | established (curated) | no MR -> candidate analysis |
| orofacial cleft | 0.559 | — | established (curated) | no MR -> candidate analysis |
| familial congenital mirror movements | 0.608 | — | established (curated) | no MR -> candidate analysis |
| lacrimal apparatus disorder | 0.566 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.474 | — | common-variant locus | no MR -> candidate analysis |
| multinodular goiter | 0.469 | — | common-variant locus | no MR -> candidate analysis |
| sweat gland disorder | 0.462 | — | common-variant locus | no MR -> candidate analysis |
| response to antihypertensive drug | 0.459 | — | common-variant locus | no MR -> candidate analysis |
| lens disorder | 0.458 | — | common-variant locus | no MR -> candidate analysis |
| color vision disorder | 0.444 | — | common-variant locus | no MR -> candidate analysis |
| bone remodeling disease | 0.441 | — | common-variant locus | no MR -> candidate analysis |
| hemorrhoid | 0.431 | — | common-variant locus | no MR -> candidate analysis |
| Tietze syndrome | 0.431 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Netrin-1) |
| gnomAD constraint | pLI=1, LOEUF=0.336 — LoF-INTOLERANT |
| GWAS Catalog | 106 unique SNPs / 235 rows |
| ClinVar | 140 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1462 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘NTN1’ and resolved to ‘Netrin-1’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 140 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 79 traits by best p-value, aggregated from 130 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O95631 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000065320/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1741307/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/NTN1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NTN1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NTN1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NTN1 — GWAS Catalog search API (live; release not exposed)