MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Ovarian cancer | -0.114 | 0.0326 | 4.90e-04 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.0185 | 0.00556 | 8.53e-04 | Wald ratio | 1 | cis | NA |
| Creatinine (enzymatic) in urine | -0.0161 | 0.0054 | 0.00291 | Wald ratio | 1 | cis | NA |
| High grade serous ovarian cancer | -0.111 | 0.039 | 0.00446 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: gout | 0.118 | 0.0421 | 0.00493 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0155 | 0.00564 | 0.00596 | Wald ratio | 1 | cis | NA |
| Endometrioid ovarian cancer | -0.2 | 0.0729 | 0.006 | Wald ratio | 1 | cis | NA |
| Heel bone mineral density (BMD) T-score automated | 0.0186 | 0.0073 | 0.0107 | Wald ratio | 1 | cis | NA |
| Myocardial infarction | 0.0708 | 0.0282 | 0.0121 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: G47 Sleep disorders | 0.156 | 0.0633 | 0.0137 | Wald ratio | 1 | cis | NA |
| Weight | -0.0118 | 0.00499 | 0.0183 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee] | -0.106 | 0.0453 | 0.0192 | Wald ratio | 1 | cis | NA |
| …and 73 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
155 association rows across 111 traits (99 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Netrin-G1 levels | 4e-545 | rs115668827 | 1 | GCST90248749 | no MR -> candidate analysis |
| Serum levels of protein NTNG1 | 8e-276 | rs115668827 | 1 | GCST90089113 | no MR -> candidate analysis |
| Sex hormone-binding globulin levels adjusted for BMI | 7e-197 | rs1730859 | 2 | GCST90012110 | no MR -> candidate analysis |
| Sex hormone-binding globulin levels | 6e-133 | rs1730859 | 8 | GCST90012111 | no MR -> candidate analysis |
| Blood protein levels | 3e-113 | rs115668827 | 1 | GCST006585 | no MR -> candidate analysis |
| Metabolic biomarkers (multivariate analysis) | 7e-97 | rs9435341 | 1 | GCST90038594 | no MR -> candidate analysis |
| Netrin-G1 levels (NTNG1.5637.81.3) | 1e-70 | rs115668827 | 1 | GCST90242050 | no MR -> candidate analysis |
| Body mass index (BMI, mean, inv-normal transformed) | 5e-36 | rs12066815 | 2 | GCST90475156 | no MR -> candidate analysis |
| Body mass index (BMI, maximum, inv-normal transformed) | 3e-35 | rs12066815 | 2 | GCST90475153 | no MR -> candidate analysis |
| Weight (mean, inv-normal transformed) | 2e-34 | rs11185092 | 2 | GCST90476463 | no MR -> candidate analysis |
| Weight (maximum, inv-normal transformed) | 4e-33 | rs11185092 | 2 | GCST90476460 | no MR -> candidate analysis |
| Total testosterone levels | 2e-28 | rs1762485 | 1 | GCST90239819 | no MR -> candidate analysis |
| …and 99 more traits (see JSON) |
Top diseases by Open Targets association (of 188 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| obesity disorder | 0.738 | — | common-variant locus | no MR -> candidate analysis |
| atypical Rett syndrome | 0.608 | — | established (curated) | no MR -> candidate analysis |
| complex neurodevelopmental disorder | 0.608 | — | established (curated) | no MR -> candidate analysis |
| overnutrition | 0.608 | — | common-variant locus | no MR -> candidate analysis |
| morbid obesity | 0.599 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.585 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.53 | — | common-variant locus | no MR -> candidate analysis |
| ovarian dysfunction | 0.436 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.431 | — | common-variant locus | no MR -> candidate analysis |
| pyogenic granuloma | 0.431 | — | common-variant locus | no MR -> candidate analysis |
| Paralytic ileus | 0.423 | — | common-variant locus | no MR -> candidate analysis |
| digestive system disorder | 0.382 | — | common-variant locus | no MR -> candidate analysis |
| spermatocele | 0.382 | — | common-variant locus | no MR -> candidate analysis |
| chronic intestinal vascular insufficiency | 0.382 | — | common-variant locus | no MR -> candidate analysis |
| bone remodeling disease | 0.369 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1, LOEUF=0.45 — LoF-INTOLERANT |
| GWAS Catalog | 68 unique SNPs / 136 rows |
| ClinVar | 102 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | 1 clinical annotations across 1 drugs |
phenome — Top 30 of 188 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘NTNG1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 102 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 20 of 111 traits by best p-value, aggregated from 155 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9Y2I2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000162631/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/NTNG1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NTNG1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NTNG1%5Bgene%5D — ClinVar build Build260809-1055.1pharmgkb: https://www.pharmgkb.org/search?query=NTNG1 — ClinPGx clinicalAnnotation via https://api.clinpgx.org/v1/datagwas_traits: https://www.ebi.ac.uk/gwas/genes/NTNG1 — GWAS Catalog search API (live; release not exposed)