Protein Dossier — NTRK3 (NT-3 growth factor receptor)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Alcohol intake frequency |
-0.0628 |
0.0232 |
0.0067 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: anxiety or panic attacks |
0.254 |
0.106 |
0.0166 |
Wald ratio |
1 |
cis |
NA |
| Years of schooling |
-0.0498 |
0.0226 |
0.0278 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: migraine |
-0.263 |
0.12 |
0.0281 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
0.32 |
0.153 |
0.0359 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G56 Mononeuropathies of upper limb |
-0.358 |
0.177 |
0.0433 |
Wald ratio |
1 |
cis |
NA |
| Chronic kidney disease |
0.199 |
0.0995 |
0.0455 |
Wald ratio |
1 |
cis |
NA |
| Hip osteoarthritis |
-0.348 |
0.181 |
0.0547 |
Wald ratio |
1 |
cis |
NA |
| Schizophrenia |
0.132 |
0.0697 |
0.0579 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: D25 Leiomyoma of uterus |
-0.424 |
0.225 |
0.0589 |
Wald ratio |
1 |
cis |
NA |
| Neo-openness to experience |
-0.842 |
0.449 |
0.0608 |
Wald ratio |
1 |
cis |
NA |
| Knee and hip osteoarthritis |
-0.264 |
0.141 |
0.0616 |
Wald ratio |
1 |
cis |
NA |
| …and 86 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2658_27_1 |
TrkC |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
110 association rows across 74 traits (63 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Bone mineral density mean |
1e-300 |
rs35620181 |
1 |
GCST90321120 |
no MR -> candidate analysis |
| Circulating NTRK3 levels |
3e-208 |
rs2009853 |
9 |
GCST90859734 |
no MR -> candidate analysis |
| NTRK3 protein levels |
3e-197 |
rs28735437 |
6 |
GCST90470098 |
no MR -> candidate analysis |
| Circulating NTF3 levels |
4e-50 |
rs9944243 |
6 |
GCST90859904 |
no MR -> candidate analysis |
| NTF3 protein levels |
2e-47 |
rs117126605 |
2 |
GCST90470094 |
no MR -> candidate analysis |
| Height |
2e-23 |
rs12441487 |
7 |
GCST90245848 |
no MR -> candidate analysis |
| Free Cholesterol to Cholesteryl Esters in Very Large HDL rat |
4e-21 |
rs150343055 |
1 |
GCST90828013 |
no MR -> candidate analysis |
| NT-3 growth factor receptor levels |
2e-20 |
rs28735437 |
3 |
GCST90248741 |
no MR -> candidate analysis |
| GLIPR1 protein levels |
8e-16 |
rs148600537 |
1 |
GCST90469357 |
no MR -> candidate analysis |
| Neurotrophin-3 levels |
1e-12 |
rs28735437 |
1 |
GCST90274829 |
no MR -> candidate analysis |
| Splenomegaly (PheCode 579.2) |
3e-12 |
rs561662177 |
1 |
GCST90480363 |
no MR -> candidate analysis |
| Total PHF-tau (SNP x SNP interaction) |
5e-12 |
rs7164988 x rs4954854 |
1 |
GCST010340 |
no MR -> candidate analysis |
| …and 62 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2978 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| neoplasm |
0.243 |
— |
established (curated) |
MR: beta=-0.233, p=0.161 (cis) |
| ovarian neoplasm |
0.596 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 1 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
4 known modulators (NT-3 growth factor receptor) |
| gnomAD constraint |
pLI=1, LOEUF=0.368 — LoF-INTOLERANT |
| GWAS Catalog |
94 unique SNPs / 183 rows |
| ClinVar |
179 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 2978 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘NTRK3’ and resolved to ‘NT-3 growth factor receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 179 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 74 traits by best p-value, aggregated from 110 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q16288 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000140538/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL5608/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/NTRK3 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NTRK3 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NTRK3%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NTRK3 — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:06:51 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none