MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Heel bone mineral density (BMD) T-score automated | 0.033 | 0.0116 | 0.0044 | Wald ratio | 1 | cis | NA |
| Pallidum volume | -19.5 | 7.51 | 0.00927 | Wald ratio | 1 | cis | NA |
| Cancer code self-reported: prostate cancer | 0.219 | 0.0848 | 0.0098 | Wald ratio | 1 | cis | NA |
| Potassium in urine | 0.0231 | 0.00908 | 0.0111 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: B37 Candidiasis | 0.62 | 0.247 | 0.012 | Wald ratio | 1 | cis | NA |
| Hearing difficulty or problems: Yes | 0.0347 | 0.0149 | 0.0201 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I30 Acute pericarditis | 0.656 | 0.293 | 0.0252 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | 0.0195 | 0.00895 | 0.0296 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.157 | 0.0736 | 0.0328 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | -0.315 | 0.15 | 0.0358 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: emphysema or chronic bronchitis | 0.138 | 0.0678 | 0.0425 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: joint disorder | 0.208 | 0.108 | 0.0534 | Wald ratio | 1 | cis | NA |
| …and 67 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
49 association rows across 43 traits (20 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Bone mineral density mean | 4e-89 | rs116356771 | 2 | GCST90321120 | no MR -> candidate analysis |
| PAM protein levels | 3e-50 | rs10477828 | 3 | GCST90470156 | no MR -> candidate analysis |
| Peroxisomal NADH pyrophosphatase NUDT12 levels (NUDT12.13947 | 3e-28 | rs74692061 | 1 | GCST90242234 | no MR -> candidate analysis |
| GLIPR1 protein levels | 9e-22 | rs567725349 | 2 | GCST90469357 | no MR -> candidate analysis |
| Type 2 diabetes | 1e-20 | rs186327337 | 3 | GCST90132184 | no MR -> candidate analysis |
| Smoking initiation | 1e-14 | rs2059067 | 1 | GCST90243985 | no MR -> candidate analysis |
| Vertex-wise sulcal depth | 2e-10 | rs76430606 | 1 | GCST90095129 | no MR -> candidate analysis |
| Gut microbial network clusters (Pink (at 1 year) x Any Breas | 3e-9 | rs7705390 | 1 | GCST90569309 | no MR -> candidate analysis |
| Total PHF-tau (SNP x SNP interaction) | 3e-9 | rs2396192 x rs17393709 | 1 | GCST010340 | no MR -> candidate analysis |
| Anatomical abnormatilies of kidney and ureters (PheCode 586. | 9e-9 | rs186637459 | 1 | GCST90651455 | no MR -> candidate analysis |
| T1 CAT volume R FrontalOrbitalCortex | 1e-8 | rs189668446 | 1 | GCST90384065 | no MR -> candidate analysis |
| Back pain | 2e-8 | rs4703253 | 1 | GCST90245851 | no MR -> candidate analysis |
| …and 31 more traits (see JSON) |
Top diseases by Open Targets association (of 70 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Back pain | 0.552 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.515 | — | common-variant locus | no MR -> candidate analysis |
| type 2 diabetes mellitus | 0.492 | — | common-variant locus | no MR -> candidate analysis |
| crush injury | 0.461 | — | common-variant locus | no MR -> candidate analysis |
| diabetes mellitus | 0.432 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.419 | — | common-variant locus | no MR -> candidate analysis |
| stroke disorder | 0.419 | — | common-variant locus | no MR -> candidate analysis |
| major depressive disorder | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| dysthymic disorder | 0.406 | — | common-variant locus | no MR -> candidate analysis |
| gastritis | 0.406 | — | common-variant locus | MR: beta=0.0523, p=0.343 (cis) |
| thyroiditis | 0.4 | — | common-variant locus | no MR -> candidate analysis |
| heart disorder | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| placenta praevia | 0.388 | — | common-variant locus | no MR -> candidate analysis |
| urolithiasis | 0.382 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 14 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=9e-14, LOEUF=1.19 — LoF-tolerant |
| GWAS Catalog | 56 unique SNPs / 99 rows |
| ClinVar | 105 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 70 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘NUDT12’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 105 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 43 traits by best p-value, aggregated from 49 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9BQG2 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000112874/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/NUDT12 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/NUDT12 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=NUDT12%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/NUDT12 — GWAS Catalog search API (live; release not exposed)