MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Cough on most days | 0.0888 | 0.0292 | 0.0024 | Wald ratio | 1 | cis | NA |
| Neuroticism | 0.0235 | 0.0088 | 0.00766 | Wald ratio | 1 | cis | NA |
| Depressive symptoms | 0.0235 | 0.0117 | 0.0455 | Wald ratio | 1 | cis | NA |
| High grade serous ovarian cancer | 0.0738 | 0.0419 | 0.0786 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0108 | 0.00625 | 0.084 | Wald ratio | 1 | cis | NA |
| Weight | -0.00928 | 0.00552 | 0.0927 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Ankle | -0.0979 | 0.059 | 0.0971 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N40 Hyperplasia of prostate | -0.117 | 0.0736 | 0.111 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: N92 Excessive frequent and irregular menstruation | 0.0631 | 0.0409 | 0.123 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: pernicious anaemia | -0.215 | 0.146 | 0.142 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | -0.331 | 0.232 | 0.154 | Wald ratio | 1 | cis | NA |
| Thalamus volume | -23.8 | 16.9 | 0.158 | Wald ratio | 1 | cis | NA |
| …and 50 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
51 association rows across 31 traits (49 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Out at first protein homolog levels | 9e-384 | rs2845705 | 3 | GCST90248768 | no MR -> candidate analysis |
| Blood protein levels | 2e-317 | rs2845705 | 2 | GCST006585 | no MR -> candidate analysis |
| Interleukin-25 levels (IL25.4137.57.2) | 6e-194 | rs2508490 | 1 | GCST90241625 | no MR -> candidate analysis |
| Serum levels of protein OAF | 6e-136 | rs2508490 | 2 | GCST90089411 | no MR -> candidate analysis |
| Interleukin-25 levels | 2e-122 | rs2508490 | 7 | GCST90161981 | no MR -> candidate analysis |
| Cerebrospinal fluid protein OAF levels | 2e-100 | rs499434 | 1 | GCST90944842 | no MR -> candidate analysis |
| EFNB2 protein levels | 2e-95 | rs2845705 | 1 | GCST90469082 | no MR -> candidate analysis |
| Out at first protein homolog levels (OAF.6414.8.3) | 2e-56 | rs117554512 | 2 | GCST90242179 | no MR -> candidate analysis |
| Protein quantitative trait loci | 9e-42 | rs562966 | 1 | GCST010900 | no MR -> candidate analysis |
| OAF protein level (protein group normalized intensity) | 3e-23 | rs2845705 | 1 | GCST90570788 | no MR -> candidate analysis |
| CLEC14A/PIK3IP1 protein level ratio | 2e-19 | rs2444239 | 1 | GCST90314080 | no MR -> candidate analysis |
| Serum urate levels | 9e-19 | rs2444239 | 3 | GCST90455669 | no MR -> candidate analysis |
| …and 19 more traits (see JSON) |
Top diseases by Open Targets association (of 40 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| gout | 0.685 | — | common-variant locus | MR: beta=-0.074, p=0.191 (cis) |
| hypertensive disorder | 0.563 | — | common-variant locus | no MR -> candidate analysis |
| disorder of patella | 0.052 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.046 | — | common-variant locus | no MR -> candidate analysis |
| obesity disorder | 0.04 | — | common-variant locus | no MR -> candidate analysis |
| corneal ulcer | 0.038 | — | common-variant locus | no MR -> candidate analysis |
| Abnormal pupillary function | 0.036 | — | common-variant locus | no MR -> candidate analysis |
| injury | 0.035 | — | common-variant locus | MR: beta=-0.331, p=0.154 (cis) |
| gram-negative bacterial infections | 0.032 | — | common-variant locus | no MR -> candidate analysis |
| smoking initiation | 0.032 | — | common-variant locus | no MR -> candidate analysis |
| seborrheic keratosis | 0.031 | — | common-variant locus | no MR -> candidate analysis |
Of the 11 rows above, 9 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.0045, LOEUF=0.918 — LoF-tolerant |
| GWAS Catalog | 60 unique SNPs / 120 rows |
| ClinVar | 92 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 40 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘OAF’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 92 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 31 traits by best p-value, aggregated from 51 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q86UD1 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000184232/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/OAF — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/OAF — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=OAF%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/OAF — GWAS Catalog search API (live; release not exposed)