MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Body mass index (BMI) | -0.034 | 0.00933 | 2.66e-04 | Wald ratio | 1 | cis | NA |
| Alzheimer’s disease | -0.226 | 0.0629 | 3.33e-04 | Wald ratio | 1 | cis | NA |
| Weight | -0.0245 | 0.00824 | 0.00298 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K44 Diaphragmatic hernia | 0.177 | 0.0629 | 0.00486 | Wald ratio | 1 | cis | NA |
| Systemic lupus erythematosus | -0.475 | 0.177 | 0.00739 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: psoriasis | 0.189 | 0.0732 | 0.00989 | Wald ratio | 1 | cis | NA |
| Sodium in urine | -0.0233 | 0.00918 | 0.0113 | Wald ratio | 1 | cis | NA |
| Fractured bone site(s): Wrist | 0.146 | 0.0578 | 0.0113 | Wald ratio | 1 | cis | NA |
| Height | -0.0289 | 0.0115 | 0.0119 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal | 0.15 | 0.0682 | 0.0276 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders | 0.225 | 0.103 | 0.0284 | Wald ratio | 1 | cis | NA |
| Neo-neuroticism | 0.749 | 0.371 | 0.0433 | Wald ratio | 1 | cis | NA |
| …and 90 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
31 association rows across 23 traits (25 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Gamma glutamyl transpeptidase | 6e-44 | rs11066453 | 1 | GCST001234 | no MR -> candidate analysis |
| 2’-5’-oligoadenylate synthase 1 levels (OAS1.10361.25.3) | 6e-26 | rs4767027 | 1 | GCST90240130 | no MR -> candidate analysis |
| Urate levels | 5e-19 | rs11066453 | 1 | GCST008972 | no MR -> candidate analysis |
| ENDOU protein levels | 7e-18 | rs2660 | 1 | GCST90469107 | no MR -> candidate analysis |
| COVID-19 (hospitalized covid vs population) | 3e-17 | rs2660 | 3 | GCST90270935 | no MR -> candidate analysis |
| Height | 2e-15 | rs11066453 | 2 | GCST90833050 | MR: beta=-0.0289, p=0.0119 (cis) |
| COVID-19 (critical illness vs population) | 3e-15 | rs2660 | 4 | GCST90270934 | no MR -> candidate analysis |
| COVID-19 severity | 1e-13 | rs10774671 | 1 | GCST90274862 | no MR -> candidate analysis |
| COVID-19 (hospitalized vs population) | 7e-13 | rs10774679 | 2 | GCST90134597 | no MR -> candidate analysis |
| 2’-5’-oligoadenylate synthase 1 levels | 1e-12 | rs1131454 | 1 | GCST90421088 | no MR -> candidate analysis |
| Alcoholic liver damage (PheCode 317.11) | 1e-11 | rs11066453 | 1 | GCST90651116 | no MR -> candidate analysis |
| SARS-CoV-2 infection | 2e-11 | rs10774671 | 2 | GCST90095125 | no MR -> candidate analysis |
| …and 11 more traits (see JSON) |
Top diseases by Open Targets association (of 375 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| pulmonary alveolar proteinosis with hypogammaglobulinemia | 0.738 | — | established (curated) | no MR -> candidate analysis |
| COVID-19 | 0.889 | — | common-variant locus | no MR -> candidate analysis |
| respiratory failure | 0.537 | — | common-variant locus | no MR -> candidate analysis |
| middle ear disorder | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| Abnormal mastoid morphology | 0.485 | — | common-variant locus | no MR -> candidate analysis |
| spinal cord injury | 0.472 | — | common-variant locus | no MR -> candidate analysis |
| age-related macular degeneration | 0.464 | — | common-variant locus | no MR -> candidate analysis |
| systemic lupus erythematosus | 0.407 | — | common-variant locus | MR: beta=-0.475, p=0.00739 (cis) |
| osteoarthritis | 0.409 | — | common-variant locus | MR: beta=-0.0266, p=0.407 (cis) |
| alcohol drinking | 0.244 | — | common-variant locus | no MR -> candidate analysis |
| gout | 0.225 | — | common-variant locus | no MR -> candidate analysis |
| alcoholic liver diseases | 0.208 | — | common-variant locus | no MR -> candidate analysis |
| major depressive disorder | 0.189 | — | common-variant locus | no MR -> candidate analysis |
| Alzheimer disease | 0.038 | — | common-variant locus | no MR -> candidate analysis |
| hypertensive disorder | 0.114 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=1.9e-05, LOEUF=0.876 — LoF-tolerant |
| GWAS Catalog | 83 unique SNPs / 166 rows |
| ClinVar | 404 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 375 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘OAS1’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 404 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 23 traits by best p-value, aggregated from 31 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P00973 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000089127/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/OAS1 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/OAS1 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=OAS1%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/OAS1 — GWAS Catalog search API (live; release not exposed)