CausalSentinel

Protein Dossier — OBP2B (Odorant-binding protein 2b)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal	0.084	0.0272	0.00201	Inverse variance weighted	2	trans	NA
Diagnoses - main ICD10: D12 Benign neoplasm of colon rectum anus and anal canal	0.084	0.0272	0.00201	Inverse variance weighted	2	cis	NA
Clear cell ovarian cancer	0.166	0.0585	0.00452	Inverse variance weighted	2	trans	NA
Clear cell ovarian cancer	0.166	0.0585	0.00452	Inverse variance weighted	2	cis	NA
HDL cholesterol	-0.0192	0.00699	0.00598	Inverse variance weighted	2	trans	NA
HDL cholesterol	-0.0192	0.00699	0.00598	Inverse variance weighted	2	cis	NA
Cancer code self-reported: malignant melanoma	0.097	0.0361	0.00711	Inverse variance weighted	2	trans	NA
Cancer code self-reported: malignant melanoma	0.097	0.0361	0.00711	Inverse variance weighted	2	cis	NA
Non-cancer illness code self-reported: depression	0.0354	0.0139	0.011	Inverse variance weighted	2	trans	NA
Non-cancer illness code self-reported: depression	0.0354	0.0139	0.011	Inverse variance weighted	2	cis	NA
Gallbladder cancer	1.8	0.709	0.0112	Wald ratio	1	cis	NA
Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip]	-0.0797	0.0316	0.0116	Inverse variance weighted	2	trans	NA
…and 155 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

182 association rows across 89 traits (177 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.

Trait	best p	lead SNP	n assoc	study	MR status
Serum alkaline phosphatase levels	3e-665	rs11244035	6	GCST90019494	no MR -> candidate analysis
CDH5/NOTCH1 protein level ratio	2e-463	rs7864821	1	GCST90313957	no MR -> candidate analysis
OBP2B protein levels	4e-225	rs147487194	8	GCST90470113	no MR -> candidate analysis
PTPRM protein levels	9e-206	rs10901241	5	GCST90470384	no MR -> candidate analysis
ABO protein levels	5e-185	rs7044834	8	GCST90468191	no MR -> candidate analysis
CDH5 protein levels	1e-183	rs10901241	6	GCST90468676	no MR -> candidate analysis
Serum levels of protein CEL	3e-115	rs146984623	1	GCST90090829	no MR -> candidate analysis
Odorant-binding protein 2b levels	8e-103	rs4962104	1	GCST90248773	no MR -> candidate analysis
Alkaline phosphatase (UKB data field 30610)	6e-101	rs189043092	8	GCST90468060	no MR -> candidate analysis
SELE protein levels	7e-99	rs189043092	5	GCST90470566	no MR -> candidate analysis
Hematological traits (multi-trait analysis)	3e-92	rs6597608	1	GCST90838669	no MR -> candidate analysis
TIE1 protein levels	2e-89	rs140728646	3	GCST90470863	no MR -> candidate analysis
…and 77 more traits (see JSON)

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

No genetically-associated diseases retrieved from Open Targets.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=0.11, LOEUF=0.783 — LoF-tolerant
GWAS Catalog	322 unique SNPs / 816 rows
ClinVar	79 records; 5 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 85 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘OBP2B’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 79 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — Top 20 of 89 traits by best p-value, aggregated from 182 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/Q9NPH6 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000171102/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/OBP2B — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/OBP2B — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=OBP2B%5Bgene%5D — ClinVar build Build260809-1055.1
• gwas_traits: https://www.ebi.ac.uk/gwas/genes/OBP2B — GWAS Catalog search API (live; release not exposed)

Provenance

• Generated: 2026-08-14T04:08:34 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

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