MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Fractured bone site(s): Other bones | 0.0329 | 0.0158 | 0.0376 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities | -0.0533 | 0.0277 | 0.0541 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | -0.0406 | 0.022 | 0.0644 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | 0.00677 | 0.00385 | 0.0789 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S66 Injury of muscle and tendon at wrist and hand level | 0.143 | 0.0822 | 0.0809 | Wald ratio | 1 | cis | NA |
| Bulimia nervosa | -0.0253 | 0.0149 | 0.0891 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R11 Nausea and vomiting | 0.0919 | 0.0547 | 0.0932 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: retinal detachment | 0.0977 | 0.0596 | 0.101 | Wald ratio | 1 | cis | NA |
| Eczema | 0.0479 | 0.0293 | 0.102 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: enlarged prostate | -0.0521 | 0.0339 | 0.124 | Wald ratio | 1 | cis | NA |
| Putamen volume | -16 | 10.4 | 0.124 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: arthritis (nos) | 0.0611 | 0.0408 | 0.134 | Wald ratio | 1 | cis | NA |
| …and 50 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
28 association rows across 23 traits (25 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Noelin-2 levels | 8e-1001 | rs55732232 | 2 | GCST90248703 | no MR -> candidate analysis |
| Serum levels of protein OLFM2 | 1e-293 | rs11669788 | 1 | GCST90090108 | no MR -> candidate analysis |
| Blood protein levels | 6e-157 | rs56243392 | 1 | GCST006585 | no MR -> candidate analysis |
| Menarche (age at onset) | 4e-31 | rs8112411 | 4 | GCST007078 | no MR -> candidate analysis |
| Protein S100-A7 protein levels (SomaScan ID:8295-16) | 6e-24 | rs56243392 | 1 | GCST90439856 | no MR -> candidate analysis |
| Heterogeneous nuclear ribonucleoprotein R protein levels (So | 1e-23 | rs56243392 | 1 | GCST90437054 | no MR -> candidate analysis |
| Impedance of arm left (UKB data field 23110) | 2e-20 | rs10413248 | 1 | GCST90468171 | no MR -> candidate analysis |
| Impedance of arm right (UKB data field 23109) | 2e-19 | rs10413248 | 1 | GCST90468172 | no MR -> candidate analysis |
| Noelin-2 level in Chronic kidney disease with hypertension a | 9e-19 | rs56243392 | 1 | GCST90238869 | no MR -> candidate analysis |
| Noelin-2 level in Chronic kidney disease with hypertension a | 1e-18 | rs56243392 | 1 | GCST90235246 | no MR -> candidate analysis |
| Appendicular lean mass | 3e-16 | rs12979274 | 1 | GCST90000025 | no MR -> candidate analysis |
| GLIPR1 protein levels | 1e-13 | rs117167271 | 1 | GCST90469357 | no MR -> candidate analysis |
| …and 11 more traits (see JSON) |
Top diseases by Open Targets association (of 1005 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Abnormality of the skeletal system | 0.464 | — | common-variant locus | no MR -> candidate analysis |
| vertebral column disorder | 0.323 | — | common-variant locus | no MR -> candidate analysis |
| liver disorder | 0.234 | — | common-variant locus | no MR -> candidate analysis |
| esophageal disorder | 0.234 | — | common-variant locus | no MR -> candidate analysis |
| musculoskeletal system disorder | 0.228 | — | common-variant locus | no MR -> candidate analysis |
| immune system disorder | 0.139 | — | common-variant locus | no MR -> candidate analysis |
| osteoarthritis | 0.097 | — | common-variant locus | no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=0.037, LOEUF=0.661 — LoF-tolerant |
| GWAS Catalog | 47 unique SNPs / 94 rows |
| ClinVar | 93 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 1005 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘OLFM2’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 93 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 23 traits by best p-value, aggregated from 28 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/O95897 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000105088/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/OLFM2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/OLFM2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=OLFM2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/OLFM2 — GWAS Catalog search API (live; release not exposed)