MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Cancer code self-reported: prostate cancer | 0.39 | 0.11 | 3.76e-04 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K20 Oesophagitis | 0.299 | 0.104 | 0.00396 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate | 0.339 | 0.122 | 0.0053 | Wald ratio | 1 | cis | NA |
| Childhood intelligence | 0.203 | 0.0761 | 0.00766 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Cataract | 0.166 | 0.0634 | 0.0089 | Wald ratio | 1 | cis | NA |
| Forearm bone mineral density | -0.205 | 0.0876 | 0.0191 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis | 0.271 | 0.123 | 0.0283 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hayfever or allergic rhinitis | 0.109 | 0.0506 | 0.0319 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R04 Haemorrhage from respiratory passages | 0.301 | 0.144 | 0.0369 | Wald ratio | 1 | cis | NA |
| Transferrin Saturation | -0.112 | 0.056 | 0.0464 | Wald ratio | 1 | cis | NA |
| Nucleus accumbens volume | 12 | 6.18 | 0.0519 | Wald ratio | 1 | cis | NA |
| Hirschsprung’s disease | 1.45 | 0.765 | 0.0583 | Wald ratio | 1 | cis | NA |
| …and 86 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
137 association rows across 79 traits (104 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating OSMR levels | 6e-1800 | rs9292723 | 6 | GCST90860497 | no MR -> candidate analysis |
| OSMR protein levels | 5e-249 | rs74924445 | 13 | GCST90470132 | no MR -> candidate analysis |
| Circulating LIFR levels | 3e-54 | rs4487517 | 3 | GCST90859867 | no MR -> candidate analysis |
| LIFR protein levels | 3e-51 | rs4487517 | 2 | GCST90469769 | no MR -> candidate analysis |
| Oncostatin-M-specific receptor subunit beta levels | 2e-35 | rs10941412 | 2 | GCST90248796 | no MR -> candidate analysis |
| Postoperative survival time in hepatocellular carcinoma | 1e-32 | rs34675408 | 2 | GCST007650 | no MR -> candidate analysis |
| ADP-ribosylation factor-like protein 5B levels | 2e-23 | rs146531093 | 1 | GCST90246577 | no MR -> candidate analysis |
| Inflammatory bowel disease | 2e-20 | rs395157 | 3 | GCST003043 | no MR -> candidate analysis |
| Red blood cell count | 3e-19 | rs357282 | 3 | GCST90662905 | no MR -> candidate analysis |
| Cerebrospinal fluid protein OSMR levels | 4e-17 | rs10472312 | 1 | GCST90945027 | no MR -> candidate analysis |
| EGFLAM protein levels | 4e-17 | rs537775424 | 1 | GCST90469084 | no MR -> candidate analysis |
| Crohn’s disease | 2e-16 | rs395157 | 3 | GCST003044 | no MR -> candidate analysis |
| …and 67 more traits (see JSON) |
Top diseases by Open Targets association (of 607 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| amyloidosis, primary localized cutaneous, 1 | 0.874 | — | established (curated) | no MR -> candidate analysis |
| familial primary localized cutaneous amyloidosis | 0.608 | — | established (curated) | no MR -> candidate analysis |
| ulcerative colitis | 0.623 | — | common-variant locus | no MR -> candidate analysis |
| inflammatory bowel disease | 0.621 | — | common-variant locus | no MR -> candidate analysis |
| Crohn disease | 0.621 | — | common-variant locus | no MR -> candidate analysis |
| venous thromboembolism | 0.533 | — | common-variant locus | no MR -> candidate analysis |
| viral infectious disease | 0.511 | — | common-variant locus | no MR -> candidate analysis |
| psoriasis | 0.5 | — | common-variant locus | MR: beta=-0.258, p=0.135 (cis) |
| sclerosing cholangitis | 0.5 | — | common-variant locus | MR: beta=-0.215, p=0.212 (cis) |
| ankylosing spondylitis | 0.5 | — | common-variant locus | MR: beta=-0.476, p=0.413 (cis) |
| macular degeneration | 0.487 | — | common-variant locus | no MR -> candidate analysis |
| neutropenia | 0.44 | — | common-variant locus | no MR -> candidate analysis |
| skin cancer | 0.355 | — | common-variant locus | no MR -> candidate analysis |
| respiratory system disorder | 0.352 | — | common-variant locus | no MR -> candidate analysis |
| external ear disorder | 0.352 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 1 known modulators (Oncostatin-M-specific receptor subunit beta) |
| gnomAD constraint | pLI=1.5e-22, LOEUF=0.975 — LoF-tolerant |
| GWAS Catalog | 97 unique SNPs / 180 rows |
| ClinVar | 247 records; 4 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 607 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘OSMR’ and resolved to ‘Oncostatin-M-specific receptor subunit beta’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 247 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 79 traits by best p-value, aggregated from 137 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q99650 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000145623/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4630885/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/OSMR — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/OSMR — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=OSMR%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/OSMR — GWAS Catalog search API (live; release not exposed)