MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Sleep duration | -0.0192 | 0.00422 | 5.23e-06 | Wald ratio | 1 | cis | NA |
| Rheumatoid arthritis | 0.105 | 0.0262 | 6.43e-05 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: R10 Abdominal and pelvic pain | 0.077 | 0.0242 | 0.00147 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.017 | 0.00541 | 0.00162 | Wald ratio | 1 | cis | NA |
| 2hr glucose | -0.127 | 0.0429 | 0.00318 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] | -0.151 | 0.0525 | 0.00407 | Wald ratio | 1 | cis | NA |
| Height | 0.0191 | 0.00665 | 0.00409 | Wald ratio | 1 | cis | NA |
| Years of schooling | -0.0236 | 0.00858 | 0.00596 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K40 Inguinal hernia | -0.0949 | 0.0364 | 0.00911 | Wald ratio | 1 | cis | NA |
| Eczema | -0.0946 | 0.0377 | 0.0121 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hypothyroidism or myxoedema | 0.0567 | 0.0227 | 0.0126 | Wald ratio | 1 | cis | NA |
| Endometrioid ovarian cancer | 0.153 | 0.0648 | 0.0184 | Wald ratio | 1 | cis | NA |
| …and 110 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
241 association rows across 101 traits (224 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Circulating PAM levels | 1e-1412 | rs35658696 | 4 | GCST90860454 | no MR -> candidate analysis |
| Peptidyl-glycine alpha-amidating monooxygenase levels | 2e-485 | rs35658696 | 3 | GCST90248972 | no MR -> candidate analysis |
| Bone mineral density mean | 1e-300 | rs564274583 | 59 | GCST90321120 | no MR -> candidate analysis |
| SCGB3A1 protein levels | 3e-132 | rs2432162 | 1 | GCST90470542 | no MR -> candidate analysis |
| Serum levels of protein PAM | 1e-126 | rs116782923 | 2 | GCST90089098 | no MR -> candidate analysis |
| PAM protein levels | 3e-80 | rs2059211 | 3 | GCST90470156 | no MR -> candidate analysis |
| Peptidyl-glycine alpha-amidating monooxygenase levels (PAM.5 | 4e-77 | rs41300805 | 3 | GCST90242214 | no MR -> candidate analysis |
| Type 2 diabetes | 3e-45 | rs78408340 | 16 | GCST90492734 | MR: beta=-0.161, p=0.0495 (cis) |
| Height | 1e-42 | rs11952361 | 8 | GCST90245848 | MR: beta=0.0191, p=0.00409 (cis) |
| Type 2 diabetes (PheCode 250.2) | 1e-35 | rs78408340 | 2 | GCST90475667 | no MR -> candidate analysis |
| Diabetes mellitus (PheCode 250) | 1e-34 | rs78408340 | 2 | GCST90475658 | no MR -> candidate analysis |
| PR interval | 2e-29 | rs114555443 | 2 | GCST010321 | no MR -> candidate analysis |
| …and 89 more traits (see JSON) |
Top diseases by Open Targets association (of 184 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| type 2 diabetes mellitus | 0.757 | 0.339 | multi-layer: burden+GWAS (allelic-series candidate) | no MR -> candidate analysis |
| diabetes mellitus | 0.879 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.838 | — | common-variant locus | no MR -> candidate analysis |
| diabetic retinopathy | 0.709 | — | common-variant locus | no MR -> candidate analysis |
| diabetic eye disease | 0.703 | — | common-variant locus | no MR -> candidate analysis |
| diabetic neuropathy | 0.692 | — | common-variant locus | no MR -> candidate analysis |
| androgenetic alopecia | 0.667 | — | common-variant locus | no MR -> candidate analysis |
| intelligence | 0.664 | — | common-variant locus | no MR -> candidate analysis |
| mathematical ability | 0.63 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes mellitus | 0.604 | — | common-variant locus | no MR -> candidate analysis |
| insomnia | 0.602 | — | common-variant locus | no MR -> candidate analysis |
| Chest pain | 0.511 | — | common-variant locus | MR: beta=0.022, p=0.352 (cis) |
| myocardial infarction | 0.51 | — | common-variant locus | MR: beta=0.0231, p=0.336 (cis) |
| urolithiasis | 0.507 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.507 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 1 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Peptidyl-glycine alpha-amidating monooxygenase) |
| gnomAD constraint | pLI=6.4e-13, LOEUF=0.718 — LoF-tolerant |
| GWAS Catalog | 151 unique SNPs / 363 rows |
| ClinVar | 159 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 184 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PAM’ and resolved to ‘Peptidyl-glycine alpha-amidating monooxygenase’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 159 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 101 traits by best p-value, aggregated from 241 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P19021 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000145730/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2544/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PAM — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PAM — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PAM%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PAM — GWAS Catalog search API (live; release not exposed)