MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Serum creatinine (eGFRcrea) | -0.00647 | 0.00139 | 3.44e-06 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions | 0.171 | 0.0475 | 3.19e-04 | Wald ratio | 1 | trans | NA |
| Non-cancer illness code self-reported: pulmonary embolism (with or without) dvt | -0.13 | 0.0481 | 0.00666 | Wald ratio | 1 | trans | NA |
| Type 2 diabetes | -0.0485 | 0.0193 | 0.0121 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: Z09 Follow-up examination after treatment for conditions other than malignant neoplasms | 0.071 | 0.0288 | 0.0137 | Wald ratio | 1 | trans | NA |
| Fracture resulting from simple fall | -0.0245 | 0.0103 | 0.018 | Wald ratio | 1 | trans | NA |
| Fractured or broken bones in last 5 years | -0.0259 | 0.0122 | 0.033 | Wald ratio | 1 | trans | NA |
| Diagnoses - main ICD10: N20 Calculus of kidney and ureter | 0.0814 | 0.0417 | 0.0512 | Wald ratio | 1 | trans | NA |
| Caudate volume | 14.8 | 7.58 | 0.0515 | Wald ratio | 1 | trans | NA |
| Eye problems or disorders: Glaucoma | 0.0576 | 0.03 | 0.0551 | Wald ratio | 1 | trans | NA |
| Neo-openness to experience | -0.198 | 0.104 | 0.0559 | Wald ratio | 1 | trans | NA |
| Haemoglobin concentration | -0.0185 | 0.00985 | 0.0603 | Wald ratio | 1 | trans | NA |
| …and 103 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
4 association rows across 4 traits (2 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| IGDCC4 protein levels | 3e-20 | rs56275228 | 1 | GCST90469523 | no MR -> candidate analysis |
| Left ventricular end systole inferoseptal wall thickness | 1e-8 | rs202032902 | 1 | GCST90278508 | no MR -> candidate analysis |
| Adolescent idiopathic scoliosis | 9e-8 | rs8027881 | 1 | GCST006287 | no MR -> candidate analysis |
| Left ventricular mass indexed by body surface area | 6e-7 | rs73468773 | 1 | GCST90244710 | no MR -> candidate analysis |
Top diseases by Open Targets association (of 45 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Genu varum | 0.351 | — | common-variant locus | no MR -> candidate analysis |
| Genu valgum | 0.351 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.291 | — | common-variant locus | no MR -> candidate analysis |
| alcohol drinking | 0.065 | — | common-variant locus | no MR -> candidate analysis |
| nephrotic syndrome | 0.062 | — | common-variant locus | no MR -> candidate analysis |
| infectious meningitis | 0.053 | — | common-variant locus | no MR -> candidate analysis |
| spondylolisthesis | 0.053 | — | common-variant locus | no MR -> candidate analysis |
Of the 7 rows above, 7 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Protein mono-ADP-ribosyltransferase PARP16) |
| gnomAD constraint | pLI=4.3e-10, LOEUF=1.19 — LoF-tolerant |
| GWAS Catalog | 26 unique SNPs / 51 rows |
| ClinVar | 77 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 45 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PARP16’ and resolved to ‘Protein mono-ADP-ribosyltransferase PARP16’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 77 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 4 of 4 traits by best p-value, aggregated from 4 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q8N5Y8 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000138617/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4105981/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PARP16 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PARP16 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PARP16%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PARP16 — GWAS Catalog search API (live; release not exposed)