CausalSentinel

Protein Dossier — PCDHB2 (Protocadherin beta-2)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Bipolar disorder	0.395	0.124	0.00143	Wald ratio	1	trans	NA
Transferrin	0.145	0.0525	0.00577	Wald ratio	1	trans	NA
Diagnoses - main ICD10: R35 Polyuria	0.356	0.139	0.0105	Wald ratio	1	trans	NA
Fractured bone site(s): Arm	0.24	0.0973	0.0138	Wald ratio	1	trans	NA
Melanoma	0.614	0.261	0.0188	Wald ratio	1	trans	NA
Triglycerides	-0.0566	0.0242	0.0196	Wald ratio	1	trans	NA
Fasting insulin	-0.0359	0.0157	0.0223	Wald ratio	1	trans	NA
Diagnoses - main ICD10: K35 Acute appendicitis	0.3	0.132	0.0227	Wald ratio	1	trans	NA
Diagnoses - main ICD10: K43 Ventral hernia	0.311	0.137	0.0228	Wald ratio	1	trans	NA
ER-positive Breast cancer (Combined Oncoarray; iCOGS; GWAS meta analysis)	-0.0918	0.0411	0.0254	Wald ratio	1	trans	NA
Happiness	-0.0334	0.0151	0.0271	Wald ratio	1	trans	NA
Glioma	-0.489	0.224	0.0293	Wald ratio	1	trans	NA
…and 94 more outcomes (see JSON)

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

No GWAS Catalog associations mapped to this gene.

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

No genetically-associated diseases retrieved from Open Targets.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=NA, LOEUF=NA — Constraint metrics missing; LoF tolerance cannot be judged.
GWAS Catalog	19 unique SNPs / 38 rows
ClinVar	152 records; 0 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 15 of 15 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘PCDHB2’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 152 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — No GWAS Catalog associations mapped to this gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/Q9Y5E7 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000112852/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/PCDHB2 — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/PCDHB2 — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PCDHB2%5Bgene%5D — ClinVar build Build260809-1055.1

Provenance

• Generated: 2026-08-14T04:12:25 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

This site is open source. Improve this page.