MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| Hearing difficulty or problems: Yes | -0.0648 | 0.0179 | 2.94e-04 | Wald ratio | 1 | cis | NA |
| Diastolic blood pressure automated reading | -0.0304 | 0.00995 | 0.00227 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M72 Fibroblastic disorders | 0.3 | 0.0991 | 0.00247 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: K29 Gastritis and duodenitis | 0.137 | 0.055 | 0.0125 | Wald ratio | 1 | cis | NA |
| Subjective well being | 0.0255 | 0.0109 | 0.0196 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: S76 Injury of muscle and tendon at hip and thigh level | 0.619 | 0.271 | 0.0224 | Wald ratio | 1 | cis | NA |
| Alcohol intake frequency | -0.0326 | 0.0144 | 0.023 | Wald ratio | 1 | cis | NA |
| Vascular or heart problems diagnosed by doctor: Angina | -0.139 | 0.0629 | 0.0271 | Wald ratio | 1 | cis | NA |
| Body mass index (BMI) | -0.0212 | 0.00971 | 0.0292 | Wald ratio | 1 | cis | NA |
| IgA nephropathy | 0.689 | 0.32 | 0.0312 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: asthma | -0.0614 | 0.029 | 0.034 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: L03 Cellulitis | 0.191 | 0.0902 | 0.0345 | Wald ratio | 1 | cis | NA |
| …and 76 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
87 association rows across 68 traits (60 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| Serum levels of protein PDGFD | 4e-245 | rs10895596 | 2 | GCST90090642 | no MR -> candidate analysis |
| Platelet-derived growth factor D levels | 1e-242 | rs7115797 | 4 | GCST90248911 | no MR -> candidate analysis |
| Blood protein levels | 3e-129 | rs10895596 | 1 | GCST006585 | no MR -> candidate analysis |
| Platelet-derived growth factor D (analyte X9341.1) levels | 9e-61 | rs7937813 | 1 | GCST90427772 | no MR -> candidate analysis |
| Height | 7e-36 | rs10791660 | 2 | GCST90245848 | MR: beta=-0.00909, p=0.435 (cis) |
| Platelet-derived growth factor D levels (PDGFD.9341.1.3) | 1e-24 | rs7950273 | 1 | GCST90242289 | no MR -> candidate analysis |
| Platelet-derived growth factor D level in Chronic kidney dis | 1e-22 | rs10895596 | 1 | GCST90239319 | no MR -> candidate analysis |
| Free Cholesterol to Cholesteryl Esters in Very Large HDL rat | 3e-19 | rs10895594 | 1 | GCST90828013 | no MR -> candidate analysis |
| MMP-12 levels | 2e-17 | rs71467219 | 2 | GCST90274905 | no MR -> candidate analysis |
| Total cholesterol levels | 2e-15 | rs11226108 | 3 | GCST90239673 | no MR -> candidate analysis |
| Occipital area | 2e-15 | rs361286 | 1 | GCST90572697 | no MR -> candidate analysis |
| Core binding factor acute myeloid leukemia | 3e-15 | rs11226158; rs11226159 | 2 | GCST008413 | no MR -> candidate analysis |
| …and 56 more traits (see JSON) |
Top diseases by Open Targets association (of 380 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| coronary artery disorder | 0.631 | — | common-variant locus | no MR -> candidate analysis |
| coronary atherosclerosis | 0.614 | — | common-variant locus | no MR -> candidate analysis |
| response to corticosteroid | 0.552 | — | common-variant locus | no MR -> candidate analysis |
| angina pectoris | 0.478 | — | common-variant locus | no MR -> candidate analysis |
| myocardial ischemia | 0.469 | — | common-variant locus | no MR -> candidate analysis |
| pulmonary vascular congestion | 0.463 | — | common-variant locus | no MR -> candidate analysis |
| connective tissue neoplasm | 0.463 | — | common-variant locus | no MR -> candidate analysis |
| Abnormality of the skeletal system | 0.452 | — | common-variant locus | no MR -> candidate analysis |
| type 1 diabetes mellitus | 0.405 | — | common-variant locus | no MR -> candidate analysis |
| celiac disease | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| cervical carcinoma | 0.396 | — | common-variant locus | no MR -> candidate analysis |
| placental abruption | 0.377 | — | common-variant locus | no MR -> candidate analysis |
| bone neoplasm | 0.371 | — | common-variant locus | no MR -> candidate analysis |
| poisoning | 0.371 | — | common-variant locus | no MR -> candidate analysis |
| Varicose veins | 0.367 | — | common-variant locus | no MR -> candidate analysis |
Of the 15 rows above, 15 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | not available — no ChEMBL target (undrugged) |
| gnomAD constraint | pLI=2.6e-07, LOEUF=0.91 — LoF-tolerant |
| GWAS Catalog | 82 unique SNPs / 143 rows |
| ClinVar | 171 records; 2 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 380 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘PDGFD’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 171 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 68 traits by best p-value, aggregated from 87 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/Q9GZP0 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000170962/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/PDGFD — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PDGFD — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PDGFD%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PDGFD — GWAS Catalog search API (live; release not exposed)