Protein Dossier — PGF (Placenta growth factor)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Diagnoses - main ICD10: M23 Internal derangement of knee |
0.153 |
0.0515 |
0.00302 |
Wald ratio |
1 |
trans |
NA |
| Body mass index (BMI) |
0.0253 |
0.00889 |
0.00444 |
Wald ratio |
1 |
trans |
NA |
| Lung cancer |
-0.265 |
0.106 |
0.0126 |
Wald ratio |
1 |
trans |
NA |
| Cough on most days |
0.0982 |
0.041 |
0.0166 |
Wald ratio |
1 |
trans |
NA |
| High grade serous ovarian cancer |
-0.161 |
0.0683 |
0.0182 |
Wald ratio |
1 |
trans |
NA |
| Weight |
0.0185 |
0.00785 |
0.0187 |
Wald ratio |
1 |
trans |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0167 |
0.00769 |
0.0301 |
Wald ratio |
1 |
trans |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
-0.188 |
0.0927 |
0.0424 |
Wald ratio |
1 |
trans |
NA |
| Eye problems or disorders: Injury or trauma resulting in loss of vision |
0.191 |
0.0959 |
0.0467 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: R07 Pain in throat and chest |
0.0734 |
0.0369 |
0.0468 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: K80 Cholelithiasis |
0.109 |
0.0557 |
0.0494 |
Wald ratio |
1 |
trans |
NA |
| Diagnoses - main ICD10: K57 Diverticular disease of intestine |
-0.14 |
0.0724 |
0.0528 |
Wald ratio |
1 |
trans |
NA |
| …and 67 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3078_1_2 |
PlGF |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
38 association rows across 34 traits (36 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating PGF levels (id: OID00384_OID20673) |
2e-202 |
rs6574205 |
1 |
GCST90859746 |
no MR -> candidate analysis |
| Circulating PGF levels (id: OID00762_OID20673) |
5e-158 |
rs6574205 |
1 |
GCST90860097 |
no MR -> candidate analysis |
| Circulating PGF levels (id: OID01493_OID20673) |
1e-156 |
rs6574205 |
1 |
GCST90860674 |
no MR -> candidate analysis |
| Cerebrospinal fluid protein ACYP1 levels |
4e-56 |
rs144552657 |
1 |
GCST90944089 |
no MR -> candidate analysis |
| ENTPD5 protein levels |
5e-30 |
rs573241313 |
1 |
GCST90469121 |
no MR -> candidate analysis |
| Alkaline phosphatase (UKB data field 30610) |
2e-21 |
rs4903273 |
1 |
GCST90468060 |
no MR -> candidate analysis |
| Circulating COL1A1 levels |
1e-20 |
rs2012627 |
1 |
GCST90859986 |
no MR -> candidate analysis |
| Septin-5 levels |
1e-19 |
rs562158551 |
1 |
GCST90423614 |
no MR -> candidate analysis |
| Serum alkaline phosphatase levels |
2e-19 |
rs10162358 |
3 |
GCST90018942 |
no MR -> candidate analysis |
| Unsupervised deep imaging phenotypes (UDIP-FA) |
1e-18 |
rs10162358 |
1 |
GCST90860937 |
no MR -> candidate analysis |
| COL1A1 protein levels |
9e-15 |
rs8005138 |
1 |
GCST90468813 |
no MR -> candidate analysis |
| Circulating WIF1 levels |
2e-14 |
rs175035 |
1 |
GCST90860083 |
no MR -> candidate analysis |
| …and 22 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 954 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hypothyroidism |
0.546 |
— |
common-variant locus |
no MR -> candidate analysis |
| acute pancreatitis |
0.459 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 2 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
3 known modulators (Placenta growth factor) |
| gnomAD constraint |
pLI=0.18, LOEUF=0.72 — LoF-tolerant |
| GWAS Catalog |
88 unique SNPs / 176 rows |
| ClinVar |
56 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 954 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PGF’ and resolved to ‘Placenta growth factor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 56 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 34 traits by best p-value, aggregated from 38 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P49763 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000119630/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1697671/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PGF — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PGF — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PGF%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PGF — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:18:32 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none