CausalSentinel

Protein Dossier — PIANP (PILR alpha-associated neural protein)

MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).

1. Published MR estimates (retrieved, not computed)

Outcome	beta	se	p	method	nSNP	cis/trans	coloc
Neuroticism	0.0265	0.0177	0.134	Wald ratio	1	cis	NA
Coronary heart disease	-0.113	0.0787	0.153	Wald ratio	1	cis	NA
Amyotrophic lateral sclerosis	0.126	0.0981	0.201	Wald ratio	1	cis	NA
Depressive symptoms	0.0221	0.0177	0.211	Wald ratio	1	cis	NA

2. pQTL instrument availability (Tier-B probe)

No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).

3. GWAS Catalog results — traits with signal at this locus

6 association rows across 4 traits (6 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.

Trait	best p	lead SNP	n assoc	study	MR status
PILR alpha-associated neural protein levels	1e-22	rs11064321	2	GCST90249001	no MR -> candidate analysis
CD4 protein levels	1e-21	rs2091780	1	GCST90468636	no MR -> candidate analysis
PILR alpha-associated neural protein levels (PIANP.9599.6.3)	5e-17	rs11064321	2	GCST90242266	no MR -> candidate analysis
Bone mineral density mean	4e-9	rs73049715	1	GCST90321120	no MR -> candidate analysis

4. Phenome map — where this gene is a genetic locus, vs. where MR exists

No genetically-associated diseases retrieved from Open Targets.

5. Downstream annotation (druggability & safety preview)

Layer	Result
ChEMBL druggability	not available — no ChEMBL target (undrugged)
gnomAD constraint	pLI=0.031, LOEUF=0.758 — LoF-tolerant
GWAS Catalog	74 unique SNPs / 148 rows
ClinVar	99 records; 5 pathogenic in sample of 30
PharmGKB/ClinPGx	no annotations

Caveats declared by the tools

• phenome — Top 30 of 39 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.
• chembl — No ChEMBL target for ‘PIANP’.
• clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 99 ClinVar records for this gene; it is a sample, not a rate.
• pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).
• gwas_traits — Top 4 of 4 traits by best p-value, aggregated from 6 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.

Sources

• uniprot: https://www.uniprot.org/uniprotkb/Q8IYJ0 — UniProt release 2026_02 (10-June-2026)
• mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0
• phenome: https://platform.opentargets.org/target/ENSG00000139200/associations — Open Targets data release 26.06
• gnomad: https://gnomad.broadinstitute.org/gene/PIANP — gnomAD constraint via GraphQL API (reference genome GRCh38)
• gwas: https://www.ebi.ac.uk/gwas/genes/PIANP — GWAS Catalog REST (live; release not exposed by this endpoint)
• clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PIANP%5Bgene%5D — ClinVar build Build260809-1055.1
• gwas_traits: https://www.ebi.ac.uk/gwas/genes/PIANP — GWAS Catalog search API (live; release not exposed)

Provenance

• Generated: 2026-08-14T04:19:59 · Tier: A
• Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
• MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
• Tool errors this run: none

This site is open source. Improve this page.