Protein Dossier — PLA2G2A (Phospholipase A2, membrane associated)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Cancer code self-reported: prostate cancer |
0.0829 |
0.0305 |
0.00649 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: vitiligo |
0.333 |
0.125 |
0.00762 |
Wald ratio |
1 |
cis |
NA |
| Fasting glucose |
0.0098 |
0.00382 |
0.0103 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: osteoarthritis |
-0.0225 |
0.00968 |
0.0202 |
Wald ratio |
1 |
cis |
NA |
| Percent emphysema |
-0.0478 |
0.0208 |
0.0213 |
Wald ratio |
1 |
cis |
NA |
| Cancer code self-reported: basal cell carcinoma |
0.0633 |
0.0277 |
0.0224 |
Wald ratio |
1 |
cis |
NA |
| Fractured or broken bones in last 5 years |
-0.0194 |
0.009 |
0.031 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: joint disorder |
-0.0978 |
0.0456 |
0.0321 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: G47 Sleep disorders |
0.073 |
0.0343 |
0.0334 |
Wald ratio |
1 |
cis |
NA |
| Bipolar disorder |
0.0586 |
0.0294 |
0.0463 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities |
0.0375 |
0.019 |
0.0488 |
Wald ratio |
1 |
cis |
NA |
| Height |
0.00706 |
0.00363 |
0.0517 |
Wald ratio |
1 |
cis |
NA |
| …and 68 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2692_74_2 |
NPS-PLA2 |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
36 association rows across 17 traits (34 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Phospholipase A2, membrane associated levels |
2e-1000 |
rs11573156 |
6 |
GCST90248834 |
no MR -> candidate analysis |
| Group IIA secretory phospholipase A2 levels in individuals w |
5e-472 |
rs11573156 |
3 |
GCST008260 |
no MR -> candidate analysis |
| Phospholipase A2, membrane associated levels (PLA2G2A.2692.7 |
2e-384 |
rs11573156 |
2 |
GCST90242257 |
no MR -> candidate analysis |
| Serum levels of protein PLA2G2A |
1e-292 |
rs11573156 |
2 |
GCST90088020 |
no MR -> candidate analysis |
| PLA2G2A protein levels |
5e-265 |
rs1588050 |
11 |
GCST90470247 |
no MR -> candidate analysis |
| Blood protein levels |
2e-111 |
rs4744 |
1 |
GCST006585 |
no MR -> candidate analysis |
| A0A3B3IRX2;PA2GA protein level (protein group normalized int |
2e-38 |
rs2307246 |
1 |
GCST90570761 |
no MR -> candidate analysis |
| Protein levels in obesity |
3e-26 |
rs10732279 |
1 |
GCST010196 |
no MR -> candidate analysis |
| Brevican core protein protein levels (SomaScan ID:2692-74) |
4e-23 |
rs11573156 |
1 |
GCST90440967 |
no MR -> candidate analysis |
| CXCL14 protein levels |
3e-17 |
rs11573156 |
1 |
GCST90468927 |
no MR -> candidate analysis |
| Circulating CCDC80 levels |
1e-16 |
rs11573156 |
1 |
GCST90860352 |
no MR -> candidate analysis |
| LECT2 protein levels |
4e-16 |
rs11573156 |
1 |
GCST90469751 |
no MR -> candidate analysis |
| …and 5 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 400 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| familial colorectal cancer |
0.547 |
— |
established (curated) |
no MR -> candidate analysis |
| ectropion |
0.448 |
— |
common-variant locus |
no MR -> candidate analysis |
| entropion |
0.448 |
— |
common-variant locus |
no MR -> candidate analysis |
| breast adenosis |
0.096 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 4 rows above, 4 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
2 known modulators (Phospholipase A2, membrane associated) |
| gnomAD constraint |
pLI=0.076, LOEUF=1.06 — LoF-tolerant |
| GWAS Catalog |
60 unique SNPs / 116 rows |
| ClinVar |
55 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 400 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PLA2G2A’ and resolved to ‘Phospholipase A2, membrane associated’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 55 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 17 of 17 traits by best p-value, aggregated from 36 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P14555 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000188257/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL3474/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PLA2G2A — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PLA2G2A — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PLA2G2A%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PLA2G2A — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:24:23 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none