Protein Dossier — PLAUR (Urokinase plasminogen activator surface receptor)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Non-cancer illness code self-reported: diverticular disease or diverticulitis |
0.298 |
0.103 |
0.00398 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K60 Fissure and fistula of anal and rectal regions |
0.392 |
0.149 |
0.00863 |
Wald ratio |
1 |
cis |
NA |
| Height |
-0.05 |
0.0195 |
0.0105 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
0.0363 |
0.0145 |
0.0126 |
Wald ratio |
1 |
cis |
NA |
| Forced vital capacity (FVC) |
-0.0294 |
0.0119 |
0.0138 |
Wald ratio |
1 |
cis |
NA |
| Hippocampus volume |
-72 |
29.8 |
0.0157 |
Wald ratio |
1 |
cis |
NA |
| Thalamus volume |
-95.6 |
39.6 |
0.0158 |
Wald ratio |
1 |
cis |
NA |
| Alzheimer’s disease |
-0.217 |
0.0995 |
0.0294 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: K40 Inguinal hernia |
0.156 |
0.0766 |
0.0417 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
-0.186 |
0.0967 |
0.055 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hyperthyroidism or thyrotoxicosis |
0.247 |
0.135 |
0.0667 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: hypertension |
0.0431 |
0.0238 |
0.0696 |
Wald ratio |
1 |
cis |
NA |
| …and 70 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-2652_15_1 |
suPAR |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
246 association rows across 155 traits (238 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Circulating TNFRSF10C levels |
3e-5702 |
rs4760 |
1 |
GCST90859942 |
no MR -> candidate analysis |
| ENG/TNFRSF10C protein level ratio |
1e-4708 |
rs4760 |
1 |
GCST90314650 |
no MR -> candidate analysis |
| Circulating TNFSF10 levels (id: OID00488_OID20611) |
3e-842 |
rs4760 |
1 |
GCST90859847 |
no MR -> candidate analysis |
| ENG/TNFSF10 protein level ratio |
2e-827 |
rs4760 |
1 |
GCST90314651 |
no MR -> candidate analysis |
| Circulating TNFSF10 levels (id: OID00672_OID20611) |
2e-702 |
rs4760 |
1 |
GCST90860016 |
no MR -> candidate analysis |
| Circulating TNFSF10 levels (id: OID00769_OID20611) |
2e-677 |
rs4760 |
1 |
GCST90860104 |
no MR -> candidate analysis |
| Circulating PLAU levels (id: OID00631_OID21124) |
4e-346 |
rs4251805 |
7 |
GCST90859976 |
no MR -> candidate analysis |
| Circulating FCGR3B levels |
3e-317 |
rs4760 |
1 |
GCST90860423 |
no MR -> candidate analysis |
| Circulating BST1 levels |
8e-309 |
rs4760 |
1 |
GCST90860619 |
no MR -> candidate analysis |
| Tumor necrosis factor receptor superfamily member 10C levels |
1e-266 |
rs4760 |
1 |
GCST90179449 |
no MR -> candidate analysis |
| Circulating PLAU levels (id: OID00481_OID21124) |
5e-247 |
rs4251805 |
7 |
GCST90859841 |
no MR -> candidate analysis |
| PLAU protein levels |
8e-200 |
rs36229204 |
5 |
GCST90470252 |
no MR -> candidate analysis |
| …and 143 more traits (see JSON) |
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|
|
|
|
4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 1776 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| abdominal aortic aneurysm |
0.792 |
— |
common-variant locus |
no MR -> candidate analysis |
| Decreased total leukocyte count |
0.727 |
— |
common-variant locus |
no MR -> candidate analysis |
| myocardial infarction |
0.585 |
— |
common-variant locus |
no MR -> candidate analysis |
| aortic aneurysm |
0.582 |
— |
common-variant locus |
no MR -> candidate analysis |
| angina pectoris |
0.573 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary artery disorder |
0.547 |
— |
common-variant locus |
no MR -> candidate analysis |
| breast carcinoma |
0.334 |
— |
common-variant locus |
no MR -> candidate analysis |
| luminal A breast carcinoma |
0.202 |
— |
common-variant locus |
no MR -> candidate analysis |
| breast cancer |
0.117 |
— |
common-variant locus |
MR: beta=0.0782, p=0.291 (cis) |
Of the 9 rows above, 8 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
0 known modulators (Urokinase plasminogen activator surface receptor) |
| gnomAD constraint |
pLI=1.6e-05, LOEUF=0.941 — LoF-tolerant |
| GWAS Catalog |
108 unique SNPs / 250 rows |
| ClinVar |
84 records; 0 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 1776 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PLAUR’ and resolved to ‘Urokinase plasminogen activator surface receptor’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 84 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 155 traits by best p-value, aggregated from 246 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q03405 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000011422/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL4883/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PLAUR — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PLAUR — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PLAUR%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PLAUR — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:26:08 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none