Protein Dossier — PLG (Plasminogen)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Weight |
0.0212 |
0.00609 |
5.16e-04 |
Wald ratio |
1 |
cis |
NA |
| Coronary heart disease |
-0.103 |
0.0303 |
6.29e-04 |
Wald ratio |
1 |
cis |
NA |
| Amygdala volume |
21.8 |
7.02 |
0.00192 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: high cholesterol |
-0.0589 |
0.0198 |
0.00293 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
0.02 |
0.0069 |
0.00375 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: bone disorder |
0.288 |
0.112 |
0.01 |
Wald ratio |
1 |
cis |
NA |
| Diastolic blood pressure automated reading |
0.0178 |
0.00706 |
0.0117 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
0.0169 |
0.00705 |
0.0165 |
Wald ratio |
1 |
cis |
NA |
| Alcohol intake frequency |
-0.0239 |
0.0102 |
0.0193 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Arm |
-0.196 |
0.0852 |
0.0216 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: C61 Malignant neoplasm of prostate |
-0.222 |
0.107 |
0.0386 |
Wald ratio |
1 |
cis |
NA |
| Fractured bone site(s): Other bones |
0.0584 |
0.0283 |
0.0392 |
Wald ratio |
1 |
cis |
NA |
| …and 77 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3710_49_2 |
Angiostatin |
Suhre K |
2019 |
prot-c-4150_75_2 |
Plasmin |
Suhre K |
2019 |
prot-c-4151_6_2 |
Plasminogen |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
1122 association rows across 433 traits (1073 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| Lipoprotein A levels (UKB data field 30790) |
1e-300 |
rs76832359 |
21 |
GCST90134488 |
no MR -> candidate analysis |
| Lipoprotein (a) levels |
8e-285 |
rs56393506 |
41 |
GCST004398 |
no MR -> candidate analysis |
| PLG protein levels |
2e-284 |
rs4252129 |
15 |
GCST90470257 |
no MR -> candidate analysis |
| Cholesterol to Total Lipids in Very Large VLDL percentage |
8e-281 |
rs56393506 |
2 |
GCST90500518 |
no MR -> candidate analysis |
| LPA protein levels |
1e-256 |
rs783184 |
19 |
GCST90469786 |
no MR -> candidate analysis |
| Lipoprotein(a) levels adjusted for apolipoprotein(a) isoform |
2e-207 |
rs186696265 |
4 |
GCST004399 |
no MR -> candidate analysis |
| Phospholipids to Total Lipids in Chylomicrons and Extremely |
4e-182 |
rs56393506 |
3 |
GCST90501339 |
no MR -> candidate analysis |
| Angiostatin levels |
2e-178 |
rs537579467 |
6 |
GCST90246505 |
no MR -> candidate analysis |
| LDL cholesterol levels x alcohol consumption (drinkers vs no |
2e-178 |
rs5014650 |
2 |
GCST008079 |
no MR -> candidate analysis |
| Plasminogen levels |
3e-176 |
rs144981713 |
6 |
GCST90249026 |
no MR -> candidate analysis |
| Free Cholesterol to Total Lipids in Large VLDL percentage |
6e-148 |
rs56393506 |
1 |
GCST90501163 |
no MR -> candidate analysis |
| Coronary artery disease |
9e-116 |
rs186696265 |
11 |
GCST90132314 |
MR: beta=-0.103, p=6.29e-04 (cis) |
| …and 421 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 3178 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| hypoplasminogenemia |
0.899 |
— |
established (curated) |
no MR -> candidate analysis |
| hereditary angioedema |
0.867 |
— |
established (curated) |
no MR -> candidate analysis |
| dysplasminogenemia |
0.745 |
— |
established (curated) |
no MR -> candidate analysis |
| myocardial infarction |
0.751 |
— |
common-variant locus |
MR: beta=-0.0634, p=0.0597 (cis) |
| coronary artery disorder |
0.804 |
— |
common-variant locus |
no MR -> candidate analysis |
| atrial fibrillation |
0.779 |
— |
common-variant locus |
MR: beta=0.0986, p=0.0972 (cis) |
| cardiovascular disorder |
0.79 |
— |
common-variant locus |
no MR -> candidate analysis |
| Hypercholesterolemia |
0.738 |
— |
common-variant locus |
MR: beta=-0.0589, p=0.00293 (cis) |
| hyperlipidemia |
0.704 |
— |
common-variant locus |
no MR -> candidate analysis |
| temporal arteritis |
0.683 |
— |
common-variant locus |
no MR -> candidate analysis |
| heart disorder |
0.672 |
— |
common-variant locus |
no MR -> candidate analysis |
| metabolic syndrome |
0.64 |
— |
common-variant locus |
no MR -> candidate analysis |
| metabolic disease |
0.635 |
— |
common-variant locus |
no MR -> candidate analysis |
| abnormal chest sounds |
0.633 |
— |
common-variant locus |
no MR -> candidate analysis |
| coronary atherosclerosis |
0.623 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 15 rows above, 12 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
9 known modulators (Plasminogen) |
| gnomAD constraint |
pLI=0.76, LOEUF=0.51 — LoF-tolerant |
| GWAS Catalog |
268 unique SNPs / 698 rows |
| ClinVar |
671 records; 3 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 3178 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PLG’ and resolved to ‘Plasminogen’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 671 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 433 traits by best p-value, aggregated from 1122 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/P00747 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000122194/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL1801/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PLG — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PLG — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PLG%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PLG — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:27:14 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: none