MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
| Outcome | beta | se | p | method | nSNP | cis/trans | coloc |
|---|---|---|---|---|---|---|---|
| LDL cholesterol | 0.0204 | 0.00578 | 4.07e-04 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: psoriasis | 0.0701 | 0.0218 | 0.0013 | Wald ratio | 1 | cis | NA |
| Total cholesterol | 0.016 | 0.00568 | 0.00483 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: high cholesterol | 0.017 | 0.0066 | 0.0102 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: chronic obstructive airways disease or copd | 0.087 | 0.039 | 0.0258 | Wald ratio | 1 | cis | NA |
| Neo-conscientiousness | 0.171 | 0.0773 | 0.027 | Wald ratio | 1 | cis | NA |
| Eye problems or disorders: Diabetes related eye disease | 0.0639 | 0.0298 | 0.0321 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: hiatus hernia | -0.0361 | 0.0169 | 0.0326 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: B37 Candidiasis | 0.207 | 0.0972 | 0.0335 | Wald ratio | 1 | cis | NA |
| Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip] | 0.0405 | 0.0198 | 0.0411 | Wald ratio | 1 | cis | NA |
| Non-cancer illness code self-reported: migraine | -0.0299 | 0.0148 | 0.0432 | Wald ratio | 1 | cis | NA |
| Microalbuminuria | 0.0454 | 0.0227 | 0.0455 | Wald ratio | 1 | cis | NA |
| …and 95 more outcomes (see JSON) |
No prot-* pQTL GWAS dataset found for this protein (matched by UniProt accession and symbol).
132 association rows across 78 traits (126 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait | best p | lead SNP | n assoc | study | MR status |
|---|---|---|---|---|---|
| PLA2G1B/PNLIPRP2 protein level ratio | 2e-10063 | rs4751996 | 1 | GCST90315664 | no MR -> candidate analysis |
| Pancreatic lipase-related protein 2 levels | 5e-2253 | rs7910135 | 1 | GCST90248850 | no MR -> candidate analysis |
| Cerebrospinal fluid protein PNLIPRP2 levels | 2e-542 | rs4751995 | 1 | GCST90944503 | no MR -> candidate analysis |
| Pancreatic lipase-related protein 2 (analyte X15471.29) leve | 9e-495 | rs4751995 | 1 | GCST90422683 | no MR -> candidate analysis |
| Blood protein levels | 2e-437 | rs7910135 | 1 | GCST006585 | no MR -> candidate analysis |
| PNLIPRP2 protein levels | 3e-303 | rs138003023 | 34 | GCST90470274 | no MR -> candidate analysis |
| Pancreatic lipase-related protein 2 level in Chronic kidney | 1e-94 | rs4751995 | 1 | GCST90238420 | no MR -> candidate analysis |
| Pancreatic lipase-related protein 2 level in Chronic kidney | 4e-57 | rs4751995 | 1 | GCST90234390 | no MR -> candidate analysis |
| PNLIPRP1 protein levels | 2e-53 | rs10885998 | 1 | GCST90470273 | no MR -> candidate analysis |
| Translin protein levels (SomaScan ID:6957-14) | 8e-48 | rs2286779 | 1 | GCST90444074 | no MR -> candidate analysis |
| PLA2G1B protein levels | 7e-39 | rs2286779 | 1 | GCST90470246 | no MR -> candidate analysis |
| Gro-gamma protein levels (SomaScan ID:15471-29) | 3e-37 | rs4751995 | 1 | GCST90441418 | no MR -> candidate analysis |
| …and 66 more traits (see JSON) |
Top diseases by Open Targets association (of 36 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease | genetic assoc. | burden (ExWAS) | causal status | MR status |
|---|---|---|---|---|
| Hypercholesterolemia | 0.717 | — | common-variant locus | MR: beta=0.0204, p=4.07e-04 (cis) |
| coronary atherosclerosis | 0.438 | — | common-variant locus | no MR -> candidate analysis |
| coronary artery disorder | 0.074 | — | common-variant locus | no MR -> candidate analysis |
| injury | 0.048 | — | common-variant locus | MR: beta=-0.112, p=0.405 (cis) |
Of the 4 rows above, 2 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
| Layer | Result |
|---|---|
| ChEMBL druggability | 0 known modulators (Pancreatic lipase-related protein 2) |
| gnomAD constraint | pLI=7.5e-16, LOEUF=1.16 — LoF-tolerant |
| GWAS Catalog | 95 unique SNPs / 190 rows |
| ClinVar | 47 records; 14 pathogenic in sample of 30 |
| PharmGKB/ClinPGx | no annotations |
phenome — Top 30 of 36 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — ChEMBL target matched by text search on ‘PNLIPRP2’ and resolved to ‘Pancreatic lipase-related protein 2’ — confirm this is the intended target.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 47 ClinVar records for this gene; it is a sample, not a rate.pharmgkb — No PharmGKB/ClinPGx clinical annotations (gene may not be a pharmacogene).gwas_traits — Top 20 of 78 traits by best p-value, aggregated from 132 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.uniprot: https://www.uniprot.org/uniprotkb/P54317 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000266200/associations — Open Targets data release 26.06chembl: https://www.ebi.ac.uk/chembl/target_report_card/CHEMBL2169728/ — ChEMBL_37 (released 2026-05-01)gnomad: https://gnomad.broadinstitute.org/gene/PNLIPRP2 — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/PNLIPRP2 — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=PNLIPRP2%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/PNLIPRP2 — GWAS Catalog search API (live; release not exposed)