Protein Dossier — POSTN (Periostin)
MR feasibility tier: A — Published pQTL-MR estimates exist for this protein (retrieved below - not computed here).
1. Published MR estimates (retrieved, not computed)
| Outcome |
beta |
se |
p |
method |
nSNP |
cis/trans |
coloc |
| Squamous cell lung cancer |
0.395 |
0.109 |
2.85e-04 |
Wald ratio |
1 |
cis |
NA |
| Lung cancer |
0.235 |
0.0736 |
0.00141 |
Wald ratio |
1 |
cis |
NA |
| Systolic blood pressure automated reading |
-0.0284 |
0.0107 |
0.00803 |
Wald ratio |
1 |
cis |
NA |
| Lung adenocarcinoma |
0.27 |
0.112 |
0.0158 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I83 Varicose veins of lower extremities |
-0.221 |
0.092 |
0.0164 |
Wald ratio |
1 |
cis |
NA |
| Body mass index (BMI) |
-0.0248 |
0.0105 |
0.0177 |
Wald ratio |
1 |
cis |
NA |
| Rheumatoid arthritis |
0.161 |
0.0701 |
0.0218 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: enlarged prostate |
-0.232 |
0.115 |
0.0427 |
Wald ratio |
1 |
cis |
NA |
| Non-cancer illness code self-reported: mania or bipolar disorder or manic depression |
0.306 |
0.155 |
0.0488 |
Wald ratio |
1 |
cis |
NA |
| Low grade serous ovarian cancer |
-0.398 |
0.207 |
0.0547 |
Wald ratio |
1 |
cis |
NA |
| Forced expiratory volume in 1-second (FEV1) |
0.0171 |
0.00905 |
0.0588 |
Wald ratio |
1 |
cis |
NA |
| Diagnoses - main ICD10: I48 Atrial fibrillation and flutter |
-0.225 |
0.126 |
0.0752 |
Wald ratio |
1 |
cis |
NA |
| …and 65 more outcomes (see JSON) |
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2. pQTL instrument availability (Tier-B probe)
| Dataset |
Trait |
Author |
Year |
prot-c-3457_57_1 |
Periostin |
Suhre K |
2019 |
3. GWAS Catalog results — traits with signal at this locus
26 association rows across 16 traits (25 genome-wide significant rows). Associations are loci, not causal claims; the mapped gene at a locus is not necessarily the effector gene.
| Trait |
best p |
lead SNP |
n assoc |
study |
MR status |
| POSTN protein levels |
4e-192 |
rs117103342 |
4 |
GCST90470288 |
no MR -> candidate analysis |
| Serum levels of protein POSTN |
4e-51 |
rs117103342 |
2 |
GCST90089547 |
no MR -> candidate analysis |
| Periostin (analyte X3457.57) levels |
1e-31 |
rs17056197 |
1 |
GCST90425776 |
no MR -> candidate analysis |
| Height |
1e-29 |
rs12871092 |
3 |
GCST90245848 |
no MR -> candidate analysis |
| Periostin levels (POSTN.6650.20.3) |
2e-28 |
rs117103342 |
2 |
GCST90242226 |
no MR -> candidate analysis |
| Smoking initiation |
7e-26 |
rs9576317 |
4 |
GCST90243968 |
no MR -> candidate analysis |
| Periostin (analyte X6645.53) levels |
8e-18 |
rs12866877 |
1 |
GCST90426806 |
no MR -> candidate analysis |
| Educational attainment |
1e-16 |
rs17257579 |
1 |
GCST90105038 |
no MR -> candidate analysis |
| Periostin levels |
9e-13 |
rs73184525 |
1 |
GCST90161797 |
no MR -> candidate analysis |
| Diastolic blood pressure |
7e-12 |
rs78641506 |
1 |
GCST90662909 |
no MR -> candidate analysis |
| Externalizing behaviour (multivariate analysis) |
9e-12 |
rs17197978 |
1 |
GCST90061435 |
no MR -> candidate analysis |
| Smoking initiation (ever regular vs never regular) (MTAG) |
3e-11 |
rs73184528 |
1 |
GCST007468 |
no MR -> candidate analysis |
| …and 4 more traits (see JSON) |
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4. Phenome map — where this gene is a genetic locus, vs. where MR exists
Top diseases by Open Targets association (of 2541 total). Associations are loci, not causal claims. The causal-status column is a four-state triage per pair: established (curated) = a curated clinical assertion exists (ClinGen/G2P/GEL/Orphanet/ClinVar — any validity level, MR adds little); exploratory rare-variant signal = ExWAS burden evidence without curation — a candidate NEW gene-disease relationship; common-variant locus = GWAS signal, classic pQTL-MR territory; multi-layer = burden+GWAS together, an allelic-series candidate (the strongest causal setup). Burden estimand is carrier-vs-noncarrier, not per-SD MR.
| Disease |
genetic assoc. |
burden (ExWAS) |
causal status |
MR status |
| smoking initiation |
0.699 |
— |
common-variant locus |
no MR -> candidate analysis |
| Varicose veins |
0.57 |
— |
common-variant locus |
MR: beta=-0.221, p=0.0164 (cis) |
| substance abuse |
0.555 |
— |
common-variant locus |
no MR -> candidate analysis |
| attention deficit-hyperactivity disorder |
0.555 |
— |
common-variant locus |
no MR -> candidate analysis |
| ankylosing spondylitis |
0.52 |
— |
common-variant locus |
no MR -> candidate analysis |
| alcohol drinking |
0.339 |
— |
common-variant locus |
no MR -> candidate analysis |
| vein disorder |
0.32 |
— |
common-variant locus |
no MR -> candidate analysis |
| lymphatic system disorder |
0.32 |
— |
common-variant locus |
no MR -> candidate analysis |
| aortic stenosis |
0.272 |
— |
common-variant locus |
no MR -> candidate analysis |
| lumbar disc herniation |
0.253 |
— |
common-variant locus |
no MR -> candidate analysis |
| palmar fibromatosis |
0.253 |
— |
common-variant locus |
no MR -> candidate analysis |
| glomerulonephritis |
0.236 |
— |
common-variant locus |
no MR -> candidate analysis |
| diabetes mellitus |
0.172 |
— |
common-variant locus |
no MR -> candidate analysis |
| ovarian neoplasm |
0.181 |
— |
common-variant locus |
no MR -> candidate analysis |
Of the 14 rows above, 13 have no MR estimate in this resource. Across all retrieved diseases for this gene: 0 exploratory rare-variant signal(s), 0 multi-layer (allelic-series candidate) pair(s). Final triage still belongs to a statistical geneticist.
5. Downstream annotation (druggability & safety preview)
| Layer |
Result |
| ChEMBL druggability |
not available — no ChEMBL target (undrugged) |
| gnomAD constraint |
pLI=3.4e-16, LOEUF=0.828 — LoF-tolerant |
| GWAS Catalog |
67 unique SNPs / 134 rows |
| ClinVar |
196 records; 1 pathogenic in sample of 30 |
| PharmGKB/ClinPGx |
no annotations |
phenome — Top 30 of 2541 associated diseases by overall score. genetic_association aggregates GWAS common-variant AND rare-variant evidence. These are ASSOCIATIONS (loci), not causal claims.chembl — No ChEMBL target for ‘POSTN’.clinvar — Pathogenic count is over the 30 record(s) retrieved, NOT over all 196 ClinVar records for this gene; it is a sample, not a rate.gwas_traits — Top 16 of 16 traits by best p-value, aggregated from 26 association rows. These are GWAS ASSOCIATIONS (loci), not causal claims; mapped genes at a locus are not necessarily the effector gene.
Sources
uniprot: https://www.uniprot.org/uniprotkb/Q15063 — UniProt release 2026_02 (10-June-2026)mr_outcomes: https://epigraphdb.org/pqtl/ — EpiGraphDB pQTL MR (Zheng et al., Nat Genet 2020) — pre-computed two-sample MR; retrieved, not computed by this agent; EpiGraphDB build 1.0, pQTL dataset v3.0phenome: https://platform.opentargets.org/target/ENSG00000133110/associations — Open Targets data release 26.06gnomad: https://gnomad.broadinstitute.org/gene/POSTN — gnomAD constraint via GraphQL API (reference genome GRCh38)gwas: https://www.ebi.ac.uk/gwas/genes/POSTN — GWAS Catalog REST (live; release not exposed by this endpoint)clinvar: https://www.ncbi.nlm.nih.gov/clinvar/?term=POSTN%5Bgene%5D — ClinVar build Build260809-1055.1gwas_traits: https://www.ebi.ac.uk/gwas/genes/POSTN — GWAS Catalog search API (live; release not exposed)
Provenance
- Generated: 2026-08-14T04:32:43 · Tier: A
- Fully mechanical: every cell above is rendered from tool return values. No language model wrote any part of this dossier.
- MR estimates, where present, are retrieved from published work (EpiGraphDB pQTL, Zheng et al. Nat Genet 2020); nothing is computed here.
- Tool errors this run: pharmgkb